Results 11 to 20 of about 5,806,293 (254)

Mode of action-based risk assessment of genotoxic carcinogens [PDF]

, 2023
The risk assessment of chemical carcinogens is one major task in toxicology. Even though exposure has been mitigated effectively during the last decades, low levels of carcinogenic substances in food and at the workplace are still present and often not ...
Jahnke, Gunnar, Lampen, Alfonso, Epe, Bernd, Hartwig, Andrea, Steinberg, Pablo, Eisenbrand, Gerhard, Arand, Michael, Rietjens, Ivonne M. C. M., Schmitz-Spanke, Simone, Monien, Bernhard, Martus, Hans-Jörg, Guth, Sabine, Schriever-Schwemmer, Gerlinde   +12 more
core   +3 more sources

Risk Assessment of Genotoxic Impurities in Drug Substances

, 2022
: This article is a review paper, based on a Literature survey to define the Genotoxic impurities present in the drug substances and drug products. Article describes the definition of Genotoxic impurities, ssources of Genotoxic impurities, formation ...
Santosh Kumar Amarbahadur Singh
core   +1 more source

Regulation of the lncRNA NEAT1 by p53-ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC. [PDF]

Mol Oncol
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
De Domenico S, La Banca V, D'Amico S, Scalera S, Nicolai S, Peschiaroli A.   +5 more
europepmc   +2 more sources

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Gauthier, Laury, Devaux, Alain, Gauthier, L., Triffault, Gaëlle, Mouchet, F., Ferrier, V., Mouchet, Florence, Jourdain, M.J., Jourdain, Marie-José, Ferrier, Vincent, Triffault, G., Mailhes, Corinne   +11 more
core   +1 more source

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]

, 2012
We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C., Chick, H.E., Kane, N.M., Baker, A.H., Thrasher, A.J., Alba, R., Fronza, R., McDonald, R.A., Delles, C., Schmidt, M., Nowrouzi, A.   +10 more
core   +1 more source

Biomonitoring of the genotoxic potential (micronucleus assay) and detoxifying activity (EROD induction) in the River Dadou (France), using the amphibian Xenopus laevis [PDF]

, 2004
Within the framework of a general survey of the water quality of the river Dadou (Tarn, France), different physicochemical parameters were measured and an inventory of the fish population was made along the water course, around the Rassisse dam.With the ...
Gauthier, Laury, Marty, Josette, Tardy, Emmanuelle, Mouchet, Florence   +3 more
core   +1 more source

Statement on the relevance of the groundwater metabolite RH‐2651 in the assessment of confirmatory data on the active substance tebufenozide

EFSA Journal, 2021
In 2018, the risk assessment for tebufenozide in light of confirmatory data requested following approval in accordance with Article 6(1) of Directive 91/414/EEC and Article 6(f) of Regulation (EC) No 1107/2009 concluded that based on the submitted data ...
European Food Safety Authority (EFSA)
doaj   +1 more source

Evaluation of genotoxic and cytotoxic effects of hydroalcoholic extract of Euphorbia tirucalli (Euphorbiaceae) in cell cultures of human leukocytes

Anais da Academia Brasileira de Ciências, 2016
Euphorbia tirucalli (L.), commonly known as aveloz, has been indiscriminately used in popular medicine to treat various illnesses. However, some components can have devastating consequences. Injury to a cell's genetic material can cause mutations, cancer,
Michel M. Machado, Luis F.S. de Oliveira, Luisa Zuravski, Raul O. de Souza, Paula Fischer, Jonathaline A. Duarte, Manoelly O. Rocha, Camila M. Güez, Aline A. Boligon, Margareth L. Athayde   +9 more
doaj   +1 more source

Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test [PDF]

, 2012
The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix.
Khadra, Ahmed, A. Khadra, Hamdi, Hassan, Hafidi, Mohamed, Bousquet‐mélou, Alain, Pinelli, Eric, Merlina, Georges, Guiresse, Agnès Maritchù, H. Hamdi, M. Guiresse, Lacroix, Marlene Z., G. Merlina, M. Hafidi, E. Pinelli, Bousquet-Mélou, Alain, M.Z. Lacroix, Guiresse, Maritxu, A. Bousquet-Melou, Hamdi, H, Hatifi, Mohamed   +19 more
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Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae [PDF]

, 2006
The present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France).
Gauthier, Laury, Gonzalez, Patrice, Boudou, Alain, Bourdineaud, Jean-Paul, Mouchet, Florence, Baudrimont, Magalie, Cuenot, Y.   +6 more
core   +1 more source