Results 211 to 220 of about 36,448 (257)
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The genotoxic risk of underground coal miners from Turkey
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2005A cytogenetic monitoring study was carried out on a group of workers from a bituminous coal mine in Zonguldak province of Turkey, to investigate the genotoxic risk of occupational exposure to coal mine dust. Cytogenetic analysis, namely sister chromatid exchanges (SCEs), chromosomal aberrations (CAs) and micronucleus (MN) tests were performed on a ...
Eyyüp Rencuzogullari +1 more
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Biological indicators of genotoxic risk and metabolic polymorphisms
Mutation Research/Reviews in Mutation Research, 2000International scientific publications on the influence of metabolic genotypes on biological indicators of genotoxic risk in environmental or occupational exposure are reviewed. Biomarkers of exposure (substance or its metabolites in biological fluids, urinary mutagenicity, protein and DNA adducts) and of effects (chromosome aberrations (CAs), sister ...
PAVANELLO, SOFIA, CLONFERO, ERMINIO
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Current methods in risk assessment of genotoxic chemicals
Food and Chemical Toxicology, 2017Chemical contaminants and residues are undesired chemicals occurring in consumer products such as food and drugs, at the workplace and in the environment, i.e. in air, soil and water. These compounds can be detected even at very low concentrations and lead frequently to considerable concerns among consumers and in the media.
Alexander, Cartus, Dieter, Schrenk
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A Strategy for the Risk Assessment of Human Genotoxic Metabolites
Chemical Research in Toxicology, 2009The role of metabolism in genotoxicity and carcinogenicity of many chemicals is well established. Accordingly, both in vitro metabolic activation systems and in vivo assays are routinely utilized for genotoxic hazard identification of drug candidates prior to clinical investigations.
Krista L, Dobo +3 more
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Sources of genotoxicity and cancer risk in ambient air
Pharmacogenetics, 1992Products of incomplete combustion are identified as a major source of carcinogenic risk in urban areas, especially those from small non-industrial sources. The major ubiquitous emission sources outdoors in populated areas are residential home heating and motor vehicles. Indoors the major combustion source is environmental tobacco smoke.
J, Lewtas +4 more
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Genotoxic alkenylbenzene flavourings, a contribution to risk assessment
Food and Chemical Toxicology, 2018Alkenylbenzenes, such as estragole, myristicin and eugenol, are present is several flavourings, functional foods, plant food supplements (PFS) and in complementary and alternative medicines (CAM) including herbal medicines. The increase in consumption in functional foods observed worldwide requires a strict analysis of the scientific validity of their ...
Célia Martins +2 more
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Genotoxic risk in rubber manufacturing industry: A systematic review
Toxicology Letters, 2014A large body of evidence from epidemiological studies among workers employed in the rubber manufacturing industry has indicated a significant excess cancer risk in a variety of sites. The International Agency for Research on Cancer has recently classified the "Occupational exposures in the rubber-manufacturing industry" as carcinogenic to humans (Group
C. Bolognesi, A. Moretto
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Genotoxicity and carcinogenicity risk of carbon nanotubes
Advanced Drug Delivery Reviews, 2013Novel materials are often commercialized without a complete assessment of the risks they pose to human health because such assessments are costly and time-consuming; additionally, sometimes the methodology needed for such an assessment does not exist. Carbon nanotubes have the potential for widespread application in engineering, materials science and ...
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Genotoxic risk evaluation of cleaning workers
Libyan Journal of Medical Sciences, 2019Background and Aim: Cleaning agents are used in large quantities by millions of people throughout the world for disinfection and surface maintenance. Although there is a complex pattern of exposure to cleaning agents and resulting health problems among cleaners, genotoxic risks of cleaners as an occupational group are uncertain.
Lale Donbak +3 more
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Dietary contribution to genotoxic risk and its control
Food and Chemical Toxicology, 1996Both exogenous and endogenous mutagens have the potential to contribute to events leading to carcinogenesis. While many dietary exogenous mutagens have been characterized, aflatoxins are the only exogenous mutagens in food which have been shown to directly increase the risk of liver cancer in humans. Little attention has been given so far to endogenous
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