Results 221 to 230 of about 36,448 (257)

Simplified protocol for evaluating the genotoxic risk of hospital wastewater

Environmental Toxicology, 2006
AbstractTo evaluate the genotoxicity of hospital wastewater, we drew up a simplified protocol based on two well‐known tests: the SOS chromotest and the Ames fluctuation test. Three concentrations of wastewater samples were directly tested without extraction or concentration. By fixing three significance levels in genotoxicity response for each test, we
B, Jolibois, M, Guerbet
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Genotoxic risk of passive smoking.

Reviews on environmental health, 1985
More than 60 chemical components are identified in cigarette smoke which have shown to be carcinogenic. The presence of these chemicals is established in mainstream smoke. However, many of them also appear in sidestream smoke resulting in pollution of indoor air, as is shown by the presence of mutagenic substances. Some rather potent carcinogens like N-
R P, Bos, P T, Henderson
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Genotoxicity in risk assessment: is it time to use a threshold approach?

Current Opinion in Toxicology, 2018
Abstract Substances that act via a genotoxic mechanism are considered to follow a low dose linear relationship with the absence of a threshold. The discussion on the existence of a threshold for genotoxic (mutagenic and clastogenic) compounds appears sometimes more an academic exercise than of practical use in public health.
Metruccio, Francesca, Moretto, Angelo
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Assessment of the genotoxic risk from laxative senna products

Environmental and Molecular Mutagenesis, 1997
Laxative senna products and several of their specific components have been submitted to a large number of genetic tests. While most studies gave negative responses, results from some of the studies suggest that components of senna products, particularly emodin and aloe-emodin, have genotoxic activity.
D, Brusick, U, Mengs
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Risk assessment of genotoxic mutagens with thresholds: A brief introduction

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2009
The demonstration and acceptance (by the scientific and regulaory community) of the concept of a threshold of genotoxic activity an have important economic implications for the use of individual ompounds [1]. The unambiguous demonstration of a threshold of enotoxic activity indicates that a compound does not produce gene utations (or chromosomal ...
Volders, Micheline, Gonzalez, Laetitia, Carmichael, Paul, Kirkland, David   +3 more
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Genotoxic risk of ethyl‐paraben could be related to telomere shortening

Journal of Applied Toxicology, 2016
AbstractThe ability of parabens to promote the appearance of multiple cancer hallmarks in breast epithelium cells provides grounds for regulatory review of the implication of the presence of parabens in human breast tissue. It is well documented that telomere dysfunction plays a significant role in the initiation of genomic instability during ...
Finot, F., Kaddour, A., Morat, L., Mouche, I., Zaguia, N., Cuceu, C., Souverville, D., Négrault, S., Cariou, O., Essahli, A., Prigent, N., Saul, J., Paillard, F., Heidingsfelder, L., Lafouge, P., Al Jawhari, M., Hempel, W. M., El May, M., Colicchio, Bruno, Dieterlen, Alain, Jeandidier, E., Sabatier, L., Clements, J., M'Kacher, R.   +23 more
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Selection of genotoxicity tests for risk assessment of effluents

Environmental Toxicology, 2000
Genotoxicity is one of the parameters within the whole effluent environmental risk procedure, an effect-based procedure developed in the Netherlands to supplement classical substance-specific risk assessment of effluents. To implement the genotoxicity parameter, one or more tests have to be selected for routine use on effluents.
P. Gert-Jan de Maagd, Marcel Tonkes
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Genotoxicity, Toxicological Profiles, and Protecting Communities at Risk

Journal of Environmental Health
This issue’s Direct From ATSDR column highlights work led and supported by the Agency for Toxic Substances and Disease Registry (ATSDR) on metal-induced genotoxicity, telomere biology, and toxicological profiles, emphasizing how these support efforts support community health protection, risk assessment, and prevention strategies.
Mohammad Shoeb, Angela Ragin, Christopher Rey, Patricia Ruiz   +3 more
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Interpretation of Genotoxicity Data in Assessing the Risks of Genetic Diseases

1986
Two aspects of genetic risk assessment have been discussed briefly. Some new results concerning the logical development of mutagenic screening programs have been reviewed. In addition, a brief introduction to quantitative risk estimation has been given.
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Some Considerations on Risk Assessment for Genotoxic and Non-genotoxic Carcinogens

Zentralblatt für Bakteriologie, 1994
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