Results 161 to 170 of about 65,731 (278)

Safety of a feed additive consisting of <i>Macleaya cordata</i> (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH). [PDF]

EFSA J
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Martelli G, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Bastos ML, Benfenati E, Brantom P, Chesson A, Schlatter J, Westendorf J, Manini P, Dusemund B.   +24 more
europepmc   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Leveraging Healthy Volunteers for Anticancer Drug Clinical Pharmacology Studies: A Review Article Featuring Futibatinib as an Example. [PDF]

Clin Transl Sci
van Haarst AD, Paglialunga S, Machnes Z, Yamamiya I, Hangai N, Oganesian A.   +5 more
europepmc   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

The genotoxic burden of toxic metals: bridging molecular mechanisms, biomonitoring, and multidisciplinary interventions. [PDF]

Front Toxicol
Imthiaz SR, Ray S, Francis GA, Vashishth R.   +3 more
europepmc   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Polystyrene nanoparticles affect development and induce genotoxicity in Drosophila melanogaster

It is estimated that more than 170 trillion plastic particles float in the World’s oceans, making plastic pollution one of the most important environmental and health emergencies.
Massimo Aloisi, Chiara Gamberi, Daniela Grifoni, Anna M. G. Poma, Patrizia Morciano   +4 more
core   +1 more source

Safety of a feed additive consisting of guar gum for all animal species (AIPG-Association for International Promotion of Gums). [PDF]

EFSA J
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Martelli G, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Vettori MV, Galobart J, Casanova JO, Innocenti ML, Gropp J.   +21 more
europepmc   +1 more source

Cytotoxic and Genotoxic Effects in Buccal Cells of Sandstone Quarry Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mineral extraction poses significant occupational health risks, particularly from respirable crystalline silica exposure. Sandstone quarrying generates substantial dust, yet evidence of its genotoxic effects remains limited. This study investigated cytogenotoxic damage in sandstone quarry workers from southern Brazil using the buccal ...
Ana Carolina de Quadros Duarte, Maria Isabela Toniazzo, Rayne Vallada da Luz, Cleisson Guimarães Bueno, Daniela Müller de Quevedo, Luciano Basso da Silva, Daiane Bolzan Berlese   +6 more
wiley   +1 more source

Acute toxicity and genotoxicity assessment of environmental contaminants using <i>Artemia salina</i>. [PDF]

Arh Hig Rada Toksikol
Aleksić JĐ, Gačić L, Kračun-Kolarević M, Marić JJ, Vuković-Gačić B, Kolarević S.   +5 more
europepmc   +1 more source