Results 91 to 100 of about 63,452 (301)

Genotoxicity effects of nano bioactive glass and Novabone bioglass on gingival fibroblasts using single cell gel electrophoresis (comet assay): An in vitro study

Dental Research Journal, 2012
Background: The greater surface of bioactive glass nanoparticles presents an incomparable and promising feature similar to the biological apatite. Nanoparticles improve cellular adhesion, enhance osteoblast proliferation and differentiation, and increase
Mohammad Tavakoli, Ensiyeh Bateni, Mansour Rismanchian, Mohammadhossein Fathi, Ali Doostmohammadi, Azim Rabiei, Hojat Sadeghi, Mahmood Etebari, Mina Mirian   +8 more
doaj   +1 more source

From Sourcing to End‐of‐Life: Sustainability Challenges and Opportunities in Organic Bioelectronics

Advanced Science, EarlyView.
Organic bioelectronics bridges biology and electronics using organic mixed ionic/electronic conductors. This Perspective addresses sustainability across the full lifecycle of organic bioelectronic materials and devices, offering a framework to guide material sourcing, synthesis, fabrication, application, and end‐of‐life strategies toward bioelectronic ...
Gwennaël Dufil, Marine Batista, Andrea Bionda, Erica Zeglio   +3 more
wiley   +1 more source

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

, 2018
<p>Although the value of the regulatory accepted batteries for in vitro genotoxicity testing is recognized, they result in a high</p> <p>number of false positives.
Philippe Vanparys, G. Ates, Gamze Ates, N. Roosens, B. Mertens, Tatyana Y. Doktorova, Anja Heymans, Dimiter Milushev, A. Heymans, Vera Rogiers, S.C.J. De Keersmaecker, Sigrid C. J. De Keersmaecker, Luc Verschaeve, Nancy H. C. Roosens, T.Y. Doktorova, L. Verschaeve, D. Milushev, P. Vanparys, V. Rogiers, Birgit Mertens   +19 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Genotoxicity produced by disease and drugs

, 2009
In humans, DNA damage or genotoxicity may be caused by exposure to outsideagents like radiation, pesticides, combustion of hydrocarbons products as well asantineoplastic drugs.
Gomez-Meda, B.C., Zamora-Perez, A.L., Gallegos-Arreola, M.P., Zuniga-Gonzalez, G.M.   +3 more
core   +1 more source

Antibacterial Activity And Genotoxicity Effect of Ethanolic Leaves Extract of Rosmarinus Officinalis

, 2020
The recent increasing use of artificial antibiotics has prompted an expansion in resistant strains and high site reactions. Medicinal plants have for quite some time been utilized as traditional medicine to treat pathogenic bacteria.
Fayez Althobaiti
core   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Genotoxicity of titanium dioxide nanoparticles [PDF]

, 2014
Titanium dioxide nanoparticles (TiO2-NPs,
Yan, Jian, Li, Yan, Chen, Tao
core   +1 more source