Results 131 to 140 of about 2,972 (172)
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The response of Ty1 test to genotoxins
Archives of Toxicology, 2008The Ty1 assay is a short-term test for detection of genotoxins based on induction of the transposition of a gene-engineered Ty1 retrotransposon in Saccharomyces cerevisiae cells. Here, we provide evidence that the Ty1 test responds positively in concentration-dependent manner to the carcinogenic genotoxins benz(a)anthracene, benzo(a)pyrene ...
M, Pesheva +4 more
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Assembly and function of a bacterial genotoxin
Nature, 2004The tripartite cytolethal distending toxin (CDT) induces cell cycle arrest and apoptosis in eukaryotic cells. The subunits CdtA and CdtC associate with the nuclease CdtB to form a holotoxin that translocates CdtB into the host cell, where it acts as a genotoxin by creating DNA lesions.
Dragana, Nesić +2 more
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to determine the biological relevance of positive genotoxicity results are costly, time consuming, and ...
Ting, Hu +6 more
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During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to determine the biological relevance of positive genotoxicity results are costly, time consuming, and ...
Ting, Hu +6 more
openaire +3 more sources
Dimethylarsine and Trimethylarsine Are Potent Genotoxins In Vitro
Chemical Research in Toxicology, 2003The mechanism of arsenic carcinogenesis is unclear. A complicating factor receiving increasing attention is that arsenic is biomethylated to form various metabolites. Eleven different arsenicals were studied for in vitro genotoxicity to supercoiled DNA (pBR 322 and phiX174).
Paul, Andrewes +2 more
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Environmental genotoxins in children and adults: Introduction and overview
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2006No abstract ...
Sarrif, A +9 more
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The proteolytic release of genotoxins from cooked beef
Biochemical and Biophysical Research Communications, 2002Dietary factors are important in the aetiology of human cancer and carcinogens, mostly heterocyclic aromatic amines, have been isolated from cooked proteinaceous foodstuffs. Whilst such carcinogens have induced tumours in rodent bioassays, the dosages required were much higher than estimates of human exposure levels.
Martin, Francis L +3 more
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1-Chloromethylpyrene: a reference skin sensitizer and genotoxin
Mutation Research Letters, 19901-Chloromethylpyrene (1-CMP) has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from benzo[a]pyrene and 1-nitropyrene. It was mutagenic to Salmonella (greater than 100 pg/plate) and exceptionally reactive to DNA when assessed by the 32P-postlabelling technique.
Ashby, J. +7 more
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Genotoxins induce binucleation in L5178Y and TK6 cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014Following the initial observation that methyl methanesulphonate induced binucleated cells in the AHH-1 line and a significant number of them contained micronuclei, human lymphoblastoid TK6 and mouse lymphoma L5178Y cells were treated with methyl methanesulphonate, methylnitrosourea, mitomycin C, cytosine arabinoside, colchicine and triton X. All except
Ann T. Doherty +7 more
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