Results 151 to 160 of about 3,926 (200)

Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells

open access: yesCellular Microbiology, 2019
Several commensal and pathogenic Gram-negative bacteria produce DNA-damaging toxins that are considered bona fide carcinogenic agents. The microbiota of colorectal cancer (CRC) patients is enriched in genotoxin-producing bacteria, but their role in the ...
Jerry W Shay   +2 more
exaly   +3 more sources

RAPD-PCR as a Rapid Approach for the Evaluation of Genotoxin-Induced Damage to Bacterial DNA

open access: yesMethods in Molecular Biology, 2017
RAPD PCR is a sensitive and reliable approach useful for the detection of DNA lesions due to environmental contaminants. In addition, this method is cost-effective, and can be performed in any laboratory having a DNA thermocycler and gel electrophoresis ...
Aldo Corsetti, Rosanna Tofalo
exaly   +2 more sources

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

open access: yesPathogens and Disease, 2017
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic Enterobacteria, and is associated with colon cancer development and acute systemic infections.
Jörn Piel, Eric Oswald, Sophie Tronnet
exaly   +2 more sources

The response of Ty1 test to genotoxins

Archives of Toxicology, 2008
The Ty1 assay is a short-term test for detection of genotoxins based on induction of the transposition of a gene-engineered Ty1 retrotransposon in Saccharomyces cerevisiae cells. Here, we provide evidence that the Ty1 test responds positively in concentration-dependent manner to the carcinogenic genotoxins benz(a)anthracene, benzo(a)pyrene ...
M, Pesheva   +4 more
openaire   +2 more sources

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