Results 161 to 170 of about 3,614 (202)

Infection with genotoxin‐producingSalmonella entericasynergises with loss of the tumour suppressorAPCin promoting genomic instability via the PI3K pathway in colonic epithelial cells

Cellular Microbiology, 2019
Several commensal and pathogenic Gram-negative bacteria produce DNA-damaging toxins that are considered bona fide carcinogenic agents. The microbiota of colorectal cancer (CRC) patients is enriched in genotoxin-producing bacteria, but their role in the ...
Oceane C B Martin, Anna Bergonzini, Federica D’Amico   +2 more
exaly   +3 more sources

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Targeting leukemia with a metabolic genotoxin

Blood, 2023
Meng Wang
exaly   +3 more sources

RAPD-PCR as a Rapid Approach for the Evaluation of Genotoxin-Induced Damage to Bacterial DNA

Methods in Molecular Biology, 2017
RAPD PCR is a sensitive and reliable approach useful for the detection of DNA lesions due to environmental contaminants. In addition, this method is cost-effective, and can be performed in any laboratory having a DNA thermocycler and gel electrophoresis ...
Rosanna Tofalo, Aldo Corsetti, Tofalo Rosanna   +2 more
exaly   +2 more sources

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway

Pathogens and Disease, 2017
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic Enterobacteria, and is associated with colon cancer development and acute systemic infections.
Sophie Tronnet, Christophe Garcie, Alexander O Brachmann   +2 more
exaly   +2 more sources

Assembly and function of a bacterial genotoxin

Nature, 2004
The tripartite cytolethal distending toxin (CDT) induces cell cycle arrest and apoptosis in eukaryotic cells. The subunits CdtA and CdtC associate with the nuclease CdtB to form a holotoxin that translocates CdtB into the host cell, where it acts as a genotoxin by creating DNA lesions.
Dragana, Nesić, Yun, Hsu, C Erec, Stebbins   +2 more
openaire   +2 more sources

Role of the sub-cellular localization of RasGAP fragment N2 for its ability to sensitize cancer cells to genotoxin-induced apoptosis

Experimental Cell Research, 2009
The specific sensitization of tumor cells to the apoptotic response induced by genotoxins is a promising way of increasing the efficacy of chemotherapies. The RasGAP-derived fragment N2, while not regulating apoptosis in normal cells, potently sensitizes
Alessandro Annibaldi, David Michod, Steeve Cruchet   +2 more
exaly   +2 more sources

The response of Ty1 test to genotoxins

Archives of Toxicology, 2008
The Ty1 assay is a short-term test for detection of genotoxins based on induction of the transposition of a gene-engineered Ty1 retrotransposon in Saccharomyces cerevisiae cells. Here, we provide evidence that the Ty1 test responds positively in concentration-dependent manner to the carcinogenic genotoxins benz(a)anthracene, benzo(a)pyrene ...
M, Pesheva, O, Krastanova, R, Stamenova, D, Kantardjiev, P, Venkov   +4 more
openaire   +2 more sources

Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to determine the biological relevance of positive genotoxicity results are costly, time consuming, and ...
Ting, Hu, David P, Gibson, Gregory J, Carr, Suzanne M, Torontali, Jay P, Tiesman, Joel G, Chaney, Marilyn J, Aardema   +6 more
openaire   +3 more sources

Dimethylarsine and Trimethylarsine Are Potent Genotoxins In Vitro

Chemical Research in Toxicology, 2003
The mechanism of arsenic carcinogenesis is unclear. A complicating factor receiving increasing attention is that arsenic is biomethylated to form various metabolites. Eleven different arsenicals were studied for in vitro genotoxicity to supercoiled DNA (pBR 322 and phiX174).
Paul, Andrewes, Kirk T, Kitchin, Kathleen, Wallace   +2 more
openaire   +2 more sources

Environmental genotoxins in children and adults: Introduction and overview

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2006
No abstract ...
Sarrif, A, Kyrtopoulos, SA, Autrup, H, Farmer, P, Kirsch-Volders, M, Kleinjans, JCS, Knudsen, LE, Mathar, U, Wiegand, H-J, Vrijhof, H   +9 more
openaire   +8 more sources