Results 161 to 170 of about 3,926 (200)

Assembly and function of a bacterial genotoxin

Nature, 2004
The tripartite cytolethal distending toxin (CDT) induces cell cycle arrest and apoptosis in eukaryotic cells. The subunits CdtA and CdtC associate with the nuclease CdtB to form a holotoxin that translocates CdtB into the host cell, where it acts as a genotoxin by creating DNA lesions.
Dragana, Nesić, Yun, Hsu, C Erec, Stebbins   +2 more
openaire   +2 more sources

Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to determine the biological relevance of positive genotoxicity results are costly, time consuming, and ...
Ting, Hu, David P, Gibson, Gregory J, Carr, Suzanne M, Torontali, Jay P, Tiesman, Joel G, Chaney, Marilyn J, Aardema   +6 more
openaire   +3 more sources

Role of the sub-cellular localization of RasGAP fragment N2 for its ability to sensitize cancer cells to genotoxin-induced apoptosis

Experimental Cell Research, 2009
The specific sensitization of tumor cells to the apoptotic response induced by genotoxins is a promising way of increasing the efficacy of chemotherapies. The RasGAP-derived fragment N2, while not regulating apoptosis in normal cells, potently sensitizes
Steeve Cruchet, Alessandro Annibaldi, David Michod   +2 more
exaly   +2 more sources

Dimethylarsine and Trimethylarsine Are Potent Genotoxins In Vitro

Chemical Research in Toxicology, 2003
The mechanism of arsenic carcinogenesis is unclear. A complicating factor receiving increasing attention is that arsenic is biomethylated to form various metabolites. Eleven different arsenicals were studied for in vitro genotoxicity to supercoiled DNA (pBR 322 and phiX174).
Paul, Andrewes, Kirk T, Kitchin, Kathleen, Wallace   +2 more
openaire   +2 more sources

Environmental genotoxins in children and adults: Introduction and overview

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2006
No abstract ...
Sarrif, A, Kyrtopoulos, SA, Autrup, H, Farmer, P, Kirsch-Volders, M, Kleinjans, JCS, Knudsen, LE, Mathar, U, Wiegand, H-J, Vrijhof, H   +9 more
openaire   +8 more sources

Living Bacterial Cell Array for Genotoxin Monitoring

Analytical Chemistry, 2004
A biosensor composed of a high-density living bacterial cell array was fabricated by inserting bacteria into a microwell array formed on one end of an imaging fiber bundle. The size of each microwell allows only one cell to occupy each well. In this biosensor, E.
David R. Walt, David R Walt*, Israel Biran   +2 more
exaly   +3 more sources

The proteolytic release of genotoxins from cooked beef

Biochemical and Biophysical Research Communications, 2002
Dietary factors are important in the aetiology of human cancer and carcinogens, mostly heterocyclic aromatic amines, have been isolated from cooked proteinaceous foodstuffs. Whilst such carcinogens have induced tumours in rodent bioassays, the dosages required were much higher than estimates of human exposure levels.
Martin, Francis L, Cole, Kathleen J, Phillips, David H, Grover, Philip L   +3 more
openaire   +3 more sources

1-Chloromethylpyrene: a reference skin sensitizer and genotoxin

Mutation Research Letters, 1990
1-Chloromethylpyrene (1-CMP) has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from benzo[a]pyrene and 1-nitropyrene. It was mutagenic to Salmonella (greater than 100 pg/plate) and exceptionally reactive to DNA when assessed by the 32P-postlabelling technique.
Ashby, J., Gallagher, J. E., Kohan, M., Tinwell, H., Kimber, I., Paton, D., Callander, R. D., Chouroulinkov, I.   +7 more
openaire   +3 more sources

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

EcoSal Plus, 2016
While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented. However, accumulating evidence indicates that we are exposed to bacterial genotoxins.
Taieb, Frederic, Petit, Claude, Nougayrede, Jean-Philippe, Oswald, Eric   +3 more
openaire   +3 more sources

Genotoxins induce binucleation in L5178Y and TK6 cells

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
Following the initial observation that methyl methanesulphonate induced binucleated cells in the AHH-1 line and a significant number of them contained micronuclei, human lymphoblastoid TK6 and mouse lymphoma L5178Y cells were treated with methyl methanesulphonate, methylnitrosourea, mitomycin C, cytosine arabinoside, colchicine and triton X. All except
Ann T. Doherty, Amy Wilson, Karolina Chocian, Jennifer Molloy, Margaret Clatworthy, Shareen Doak, Gareth Jenkins, Mike O’Donovan   +7 more
openaire   +4 more sources