Results 171 to 180 of about 3,614 (202)

Eugenol—an in vivo genotoxin?

Food and Chemical Toxicology, 1996
exaly   +2 more sources

Living Bacterial Cell Array for Genotoxin Monitoring

Analytical Chemistry, 2004
A biosensor composed of a high-density living bacterial cell array was fabricated by inserting bacteria into a microwell array formed on one end of an imaging fiber bundle. The size of each microwell allows only one cell to occupy each well. In this biosensor, E.
Israel Biran, David R Walt, David R Walt*   +2 more
exaly   +3 more sources

The proteolytic release of genotoxins from cooked beef

Biochemical and Biophysical Research Communications, 2002
Dietary factors are important in the aetiology of human cancer and carcinogens, mostly heterocyclic aromatic amines, have been isolated from cooked proteinaceous foodstuffs. Whilst such carcinogens have induced tumours in rodent bioassays, the dosages required were much higher than estimates of human exposure levels.
Martin, Francis L, Cole, Kathleen J, Phillips, David H, Grover, Philip L   +3 more
openaire   +3 more sources

1-Chloromethylpyrene: a reference skin sensitizer and genotoxin

Mutation Research Letters, 1990
1-Chloromethylpyrene (1-CMP) has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from benzo[a]pyrene and 1-nitropyrene. It was mutagenic to Salmonella (greater than 100 pg/plate) and exceptionally reactive to DNA when assessed by the 32P-postlabelling technique.
Ashby, J., Gallagher, J. E., Kohan, M., Tinwell, H., Kimber, I., Paton, D., Callander, R. D., Chouroulinkov, I.   +7 more
openaire   +3 more sources

Genotoxins induce binucleation in L5178Y and TK6 cells

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
Following the initial observation that methyl methanesulphonate induced binucleated cells in the AHH-1 line and a significant number of them contained micronuclei, human lymphoblastoid TK6 and mouse lymphoma L5178Y cells were treated with methyl methanesulphonate, methylnitrosourea, mitomycin C, cytosine arabinoside, colchicine and triton X. All except
Ann T. Doherty, Amy Wilson, Karolina Chocian, Jennifer Molloy, Margaret Clatworthy, Shareen Doak, Gareth Jenkins, Mike O’Donovan   +7 more
openaire   +4 more sources

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

EcoSal Plus, 2016
While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented. However, accumulating evidence indicates that we are exposed to bacterial genotoxins.
Taieb, Frederic, Petit, Claude, Nougayrede, Jean-Philippe, Oswald, Eric   +3 more
openaire   +3 more sources

Ames positive boronic acids are not all eukaryotic genotoxins

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015
Boronic acids and their derivatives have been exploited for their pharmacological activity and their utility as intermediates in the synthesis of novel non-boron containing compounds. A recent study reported that boronic acids are bacterial mutagens. Here, results are reported from the testing of nine boronic acids using the pan-mechanistic eukaryotic ...
Walmsley, Richard, Scott, Heather
openaire   +2 more sources

Schistosome related cancers: A possible role for genotoxins

Environmental Mutagenesis, 1985
AbstractSchistosomiasis has long been associated with cancer. This association is most prevalent between Schistosoma hematobium and bladder cancer. Numerous theories have been proposed to explain the causal link between the parasite infestation and the ensuing neoplasia. One theory that has not received as much attention as others, however, is the role
openaire   +2 more sources

Genotoxin-Induced Apoptosis: Implications for Carcinogenesis

1994
Apoptosis is thought to be a programmed form of cell death which, when balanced by cell proliferation, contributes to the regulation of tissue homeostasis (1). An imbalance between apoptosis and proliferation may be a factor in tumorigenesis. Apoptosis differs from necrosis both morphologically and biochemically. Necrotic cells exhibit an early loss of
Steven R. Patierno, Lori J. Blankenship, John P. Wise, Jian Xu, Laura C. Bridgewater, Francis C. R. Manning   +5 more
openaire   +1 more source

Colibactin: understanding an elusive gut bacterial genotoxin

Natural Product Reports, 2015
This highlight reviews recent studies of colibactin, a structurally uncharacterized genotoxin synthesized by members of the human gut microbiota.
openaire   +2 more sources