Results 61 to 70 of about 302,540 (297)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Invited review: Phenotyping strategies and quantitative-genetic background of resistance, tolerance and resilience associated traits in dairy cattle

Animal, 2019
In dairy cattle, resistance, tolerance and resilience refer to the adaptation ability to a broad range of environmental conditions, implying stable performances (e.g. production level, fertility status) independent from disease or infection pressure. All
S. König, K. May
doaj   +1 more source

Genotype By Environment Interaction And Yield Stability Of Soybean Genotypes [PDF]

, 2018
Soybean breeding program in Indonesia has been actively involved in improving the genetic yield potential to meet the needs of farmers in different parts of the country.
Adie, M. M. (M), Krisnawati, A. (Ayda)
core  

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Genotype by Environment Interactions in Livestock Farming

, 2022
Genotype by environment interaction, often referred to as “GxE,” is the phenomenon for which the breeding value of an individual depends on the environmental conditions and the effect of an environmental factor depends on the individ- ual’s genetic background.
Tiezzi Francesco, Maltecca Christian
openaire   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Interaksi Genotipe X Lingkungan Hasil dan Komponen Hasil 14 Genotipe Tomat di Empat Lingkungan Dataran Rendah [PDF]

, 2015
Genotype x environment interaction (GxE) information is needed by plant breeders to assist the identification of superior genotype. Stability analysis can be done if there is a GxE interaction, to show the stability of a genotype when planted in ...
Dewi, S. M. (Suprayanti), Sobir, S. (Sobir), Syukur, M. (Muhamad)   +2 more
core  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Genotype by environment interactions for growth in Red Angus [PDF]

Journal of Animal Science, 2017
Accuracy of sire selection is limited by how well animals are characterized for their environment. The objective of this study was to evaluate the presence of genotype × environment interactions (G×E) for birth weight (BiW) and weaning weight (WW) for Red Angus in the United States. Adjusted weights were provided by the Red Angus Association of America.
Fennewald, D. J., Weaber, Robert L., Lamberson, W. R.   +2 more
openaire   +3 more sources