Results 91 to 100 of about 1,614,514 (332)

Deconstructing the sources of genotype-phenotype associations in humans

Science, 2019
Efforts to link variation in the human genome to phenotypes have progressed at a tremendous pace in recent decades. Most human traits have been shown to be affected by a large number of genetic variants across the genome.
Alexander I. Young, S. Benonisdottir, M. Przeworski, A. Kong   +3 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan [PDF]

, 2001
Etsuro Orito, Takafumi Ichida, Hiroshi Sakugawa, Michio Sata, Norio Horiike, Keisuke Hino, Kiwamu Okita, Takeshi Okanoue, Shiro Iino, Eiji Tanaka, Kazuyuki Suzuki, Hisayoshi Watanabe, Shuhei Hige, Masashi Mizokami   +13 more
openalex   +1 more source

Effects of Genotype and Climatic Conditions on the Oil Content and Its Fatty Acids Composition of Carthamus tinctorius L. Seeds [PDF]

, 2021
Kamel Zemour, Ahmed Adda, Amina Labdelli, Abdelkader Dellal, Muriel Cerny, Othmane Merah   +5 more
openalex   +1 more source

Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource

Hepatology, 2013
The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an agreed and uniform nomenclature for HCV variants and the criteria for their assignment into genotypes and subtypes. Since its publication, the available dataset of
Donald B. Smith, J. Bukh, C. Kuiken, A. Muerhoff, C. Rice, J. Stapleton, P. Simmonds   +6 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Long-term effects of stand density management and genotype on wood properties of loblolly pine (Pinus taeda L.) in the mid-South USA

, 2021
Michael A. Blazier, Thomas Hennessey, Laurence R. Schimleck, Scott Abbey, Ryan Holbrook, Joseph Dahlen   +5 more
openalex   +2 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Hepatitis B virus S gene escape mutants

Asian Journal of Transfusion Science, 2007
Hepatitis B virus (HBV) can be classified into nine immunological subtypes or eight genotypes. The most prevalent genotypes in Asia are genotypes B and C. HBV is transmitted parenteraly and can produce either asymptomatic or symptomatic disease. Although
Purdy Michael
doaj  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source