ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy
Circulation, 2018 Background: A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is critically needed to improve patient management and outcomes.
Carolyn Y. Ho +19 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Statistical methods for detecting genes associated with sperm competition in natural populations of Drosophila, using blocks of tightly linked single nucleotide polymorphisms : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Statistics at Massey University, Albany, New Zealand [PDF]
, 2007 The purpose of the project is to develop statistical methods for detecting genes associated with sperm competition in natural populations of Drosophila (fruit flies). The flies' genotype information given by Fiumera et al.
Werner, Lillian Li
core
A variance components factor model for genetic association studies: a Bayesian analysis.
, 2010 Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
core +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Anderson Localization, Non-linearity and Stable Genetic Diversity
, 2006 In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and mutation.
Charles L. Epstein +19 more
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Transference of the Term "Genotype" [PDF]
Science, 1911 n ...
Bather, F. A., Calman, W. T.
openaire +3 more sources
Molecular genotype in migraine [PDF]
The Journal of Headache and Pain, 2015 Migraine is an episodic brain disorder with disabling attacks of headache that are associated with nausea, vomiting, and hypersensitivity to light, sound, and smell. According to major criteria of the International Classification of Headache Disorders (ICHD-II) from the International Headache Society (IHS), migraine is divided into two main subtypes ...
Gaetano S. Grieco +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source