Results 81 to 90 of about 2,122,472 (401)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention

Anais da Academia Brasileira de Ciências
Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an ...
GREICE G. MORAES, CÉZANE P. REUTER, JANE D.P. RENNER, ELISA I. KLINGER, MICHELE B. FERREIRA, ELZA D. DE MELLO, ANDRÉIA DE M. VALIM, MIRIA S. BURGOS   +7 more
doaj   +1 more source

Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger

International Journal of Infectious Diseases, 2016
Objectives: In Niger, 65% of hepatocarcinoma and 75% of cirrhosis cases were due to hepatitis B virus (HBV). We studied the genotypic characteristics of HBsAg in chronically HBV-infected patients in Niamey. Methods: We studied prospectively HBV genotypic
Souleymane Brah, Sahada Moussa, Achirou Inoua, Daouda Maiga Alhousseini, Mamane Daou, Boubacar Madougou, Marie-Hélène Romera, Adamou Hamadou, Eric Adehossi, Philippe Parola, Philippe Colson   +10 more
doaj   +1 more source

Phenotype Search Trajectory Networks for Linear Genetic Programming [PDF]

arXiv, 2022
Genotype-to-phenotype mappings translate genotypic variations such as mutations into phenotypic changes. Neutrality is the observation that some mutations do not lead to phenotypic changes. Studying the search trajectories in genotypic and phenotypic spaces, especially through neutral mutations, helps us to better understand the progression of ...
arxiv  

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
BACKGROUND: Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme (
Devadason, D, Dhamrait, S, Harding, DR, Humphries, SE, Marlow, N, Montgomery, HE, Whitelaw, A   +6 more
core   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Mutation and Transmission Profiles of Second-Line Drug Resistance in Clinical Isolates of Drug-Resistant Mycobacterium tuberculosis From Hebei Province, China

Frontiers in Microbiology, 2019
The emergence of drug-resistant tuberculosis (TB) is involved in ineffective treatment of TB, especially multidrug resistant/extensively resistant TB (MDR/XDR-TB), leading to acquired resistance and transmission of drug-resistant strains.
Qianlin Li, Huixia Gao, Zhi Zhang, Yueyang Tian, Tengfei Liu, Yuling Wang, Jianhua Lu, Yuzhen Liu, Erhei Dai   +8 more
doaj   +1 more source

PhenoScanner: a database of human genotype–phenotype associations

Bioinform., 2016
Summary: PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of genetic variants with many phenotypes, to help aid ...
James R. Staley, James A. Blackshaw, M. Kamat, Steve Ellis, P. Surendran, B. Sun, D. Paul, Daniel F. Freitag, S. Burgess, J. Danesh, R. Young, A. Butterworth   +11 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Transference of the Term "Genotype" [PDF]

Science, 1911
n ...
Bather, F. A., Calman, W. T.
openaire   +4 more sources