Results 71 to 80 of about 404,477 (319)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Prevalence of colonization and mitochondrial large subunit rRNA mutation of Pneumocystis jiroveci among Iranian children

Iranian Journal of Microbiology, 2016
Background and Objectives: Pneumocystis jiroveci is an important causative agent of Pneumocystis pneumonia. During childhood, exposure to Pneumocystis occurs and antibody was built in early childhood.
Parisa Badiee, Ali Rezapour, Amin Abbasian, Hamid Reza Foroutan, Hadis Jafarian   +4 more
doaj  

The Eye of the Chiropterologist: Phenotypic Versus Genotypic Identification of Bats

Ecology and Evolution
Bats are a diverse and ecologically important group of mammals that play critical roles in ecosystems. Accurate identification is necessary to comprehend bat species' ecology and behavior to further the conservation of bats. Both phenotypic and genotypic
F. D. Dami, T. E. Adeyanju, A. A. Chaskda, I. M. Okpanachi, A. T. Adeyanju, S. M. Ezekiel, T. Gwom, I. A. Iniunam, A. Hitch, D. D. Pam, P. Luka, S. C. Weaver, S. Paessler, R. W. Cross, N. Shehu   +14 more
doaj   +1 more source

Phenotypic and molecular analysis of Pseudomonas aeruginosa virulence and association with antibiotic resistance in Egypt

Journal of Infection in Developing Countries
Introduction: Pseudomonas aeruginosa is a common nosocomial pathogen with multidrug resistance (MDR) and virulence factors (VFs). This study assessed the VFs and their associations with MDR and non-MDR isolates.
Salah AI Ali, Aya A Ghamry, Amal M Soliman, Abdullah M Abdo, Nagwan G El-Menofy, Manal M Al-Gerby, Haytham K Mahrous   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Sensors for Antibiotics Susceptibility Testing—Recent Advances

Advanced Sensor Research
The age of antibiotics, which began with the discovery of penicillin in 1929, marks an important period in medical history, as deadly bacterial infections seemed to be a thing of the past.
Oliver Riester, Stefan Laufer, Roland Mertelsmann, Hans‐Peter Deigner   +3 more
doaj   +1 more source

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing

PLoS ONE, 2015
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and middle-income countries (LMICs) hardest hit by the HIV-1 pandemic.
Soo-Yon Rhee, M. Jordan, E. Raizes, A. Chua, N. Parkin, R. Kantor, G. V. Van Zyl, I. Mukui, M. Hosseinipour, L. Frenkel, N. Ndembi, R. Hamers, T. F. Rinke de Wit, C. Wallis, Ravindra K. Gupta, J. Fokam, C. Zeh, J. Schapiro, S. Carmona, D. Katzenstein, Michele W. Tang, A. Aghokeng, Túlio de Oliveira, A. Wensing, J. Gallant, M. Wainberg, D. Richman, J. Fitzgibbon, M. Schito, S. Bertagnolio, Chunfu Yang, R. Shafer   +31 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

High proportion of tuberculosis recent transmission in rural areas of Northeastern China: a 3-year prospective population-based genotypic and spatial analysis in Hinggan League, China

Microbiology Spectrum
Tuberculosis (TB) remains a significant public health challenge in China, particularly in rural areas like Hinggan League (HL), Inner Mongolia. Understanding the genetic diversity and transmission dynamics of Mycobacterium tuberculosis (MTB) strains is ...
Xichao Ou, Xiangchen Li, Shaojun Pei, Bing Zhao, Liping Feng, Chong Teng, Yewei Lu, Hanfang Zhu, Yang Zhou, Hui Xia, Zhengwei Liu, Xiaomeng Wang, Yanling Wang, Richard Anthony, Yanlin Zhao   +14 more
doaj   +1 more source