Results 201 to 210 of about 58,106,402 (334)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Genetic diversity of Camelina sativa: implications for sustainable crop improvement through Genotyping-by-Sequencing (GBS). [PDF]

BMC Plant Biol
Karimzadeh P, Rashidi-Monfard S, Kahrizi D, Haghi R.   +3 more
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Genotyping-by-sequencing -based genome-wide SNP profiling and DNA fingerprinting of Saudi Arabian faba bean germplasm. [PDF]

BMC Plant Biol
Almarri NB, Ahmad S, Alsofuani NM, Osman S, Ibrahim MA, Mostafa SM, Al-Haidar OA, Alomran SM, Alrashidi I, Tariq R.   +9 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

SimGBS: a rapid method for simulating large-scale genotyping-by-sequencing data. [PDF]

BMC Bioinformatics
Kang J, Hess MK, Dodds KG, Brauning R, McEwan JC, Foote BJ, Foote JF, Konkolewska A, Clarke SM, Hess AS.   +9 more
europepmc   +1 more source

Detection of individual ploidy levels with genotyping‐by‐sequencing (GBS) analysis

Molecular Ecology Resources, 2017
Z. Gompert, K. Mock
semanticscholar   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Genetic mapping of quantitative trait loci associated with nematode resistance in melon using genotyping-by-sequencing. [PDF]

Front Plant Sci
Sharma M, Kaur A, Bhatia SK, Sharma SP, Kaur S, Narang D, Leela NC, Kumari N, Sarao NK.   +8 more
europepmc   +1 more source

Developing a pipeline for genotyping-by-sequencing (GBS) of the New Zealand Greenshell™ Mussel

, 2017
The reduction in costs of Next Generation Sequencing has enabled the development of high throughput methods, such as Genotyping-By-Sequencing (GBS), for genotyping multiple individuals from a species cheaply and efficiently.
Rudiger Brauning (47247), Hayley Baird (8845760), Shannon Clarke (3504989), Rachael Ashby (15393782), Tracey Van Stijn (10380614), Neil Gemmell (279711), Chris Brown (16877)   +6 more
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