Results 221 to 230 of about 55,908,906 (258)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
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Genotyping‐by‐Sequencing

Current Protocols in Plant Biology, 2017
AbstractGenotyping‐by‐sequencing (GBS) refers to a suite of related methods that obtain genotype data from samples by using restriction enzyme digestion followed by high‐throughput sequencing. GBS is a refinement of restriction site–associated DNA sequencing (RADseq) methods, with a goal of being able to perform library preparations quickly, cost ...
Jason G, Wallace, Sharon E, Mitchell
openaire   +2 more sources

Genotyping-by-Sequencing Technology in Plant Taxonomy and Phylogeny [PDF]

, 2020
Genotyping-by-sequencing (GBS) is a method to discover and genotype simultaneous genome-wide high-throughput single nucleotide polymorphisms (SNPs). GBS is based on reducing genome complexity with restriction enzymes. Here we describe a method developed by Elshire et al.
Favre, Félicien, Jourda, Cyril, Besse, Pascale, Charron, Carine   +3 more
openaire   +3 more sources

Design of a High Density SNP Genotyping Assay in the Pig Using SNPs Identified and Characterized by Next Generation Sequencing Technology [PDF]

PLoS ONE, 2009
A systematic review of the literature was carried out to determine the evidence for the reliability and validity of the assessment methods used in veterinary medical education. The review followed the approach used by the Best Evidence Medical Education (
Robert Schnabel, Alan L Archibald, Hendrik-Jan Megens   +2 more
exaly   +2 more sources

Methods for Genotyping-by-Sequencing

2016
A major goal for biologists is to understand the connection between genes and phenotypic traits, and genetic mapping in experimental populations remains a powerful approach for discovering the causal genes underlying phenotypes. For genetic mapping, the process of genotyping was previously a major rate-limiting step.
Rowan, B., Seymour, D., Chae, E., Lundberg, D., Weigel, D.   +4 more
openaire   +3 more sources

Skim-Based Genotyping by Sequencing

2014
Genotyping by sequencing (GBS) is a relatively new method used to determine the differences in the genetic makeup of individuals. Its novelty stems from a combination of two already available methods: genotyping and next-generation sequencing. Depending on the individual study design GBS protocols can take multiple forms, however most share a sequence ...
Golicz, Agnieszka A., Bayer, Philipp E., Edwards, David   +2 more
openaire   +5 more sources

Genotyping by sequencing for SNP marker development in onion

Genome, 2020
Onion (Allium cepa) is not highly tractable for development of molecular markers due to its large (16 gigabases per 1C) nuclear genome. Single nucleotide polymorphisms (SNPs) are useful for genetic characterization and marker-aided selection of onion because of codominance and common occurrence in elite germplasm. We completed genotyping by sequencing
Labate, Joanne A., Glaubitz, Jeffrey C., Havey, Michael J.   +2 more
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Genotyping-by-Sequencing in Potato

2017
Genotyping-by-sequencing (GBS) is one of the most cost-effective approaches to sequencing in potato (SNP) discovery and genotyping. The reduction of genome complexity that is central to the GBS approach is useful in the analysis of many plant genomes in which large size and polyploidy can prove challenging.
Chiheb Boudhrioua, Maxime Bastien, Gaétan Légaré, Sonia Pomerleau, Jérôme St-Cyr, Brian Boyle, François Belzile   +6 more
openaire   +1 more source

Genotyping-by-Sequencing on the Ion Torrent Platform in Barley

2018
The characterization of genetic polymorphism is a crucial step in both genetic studies and breeding programs. Genotyping-by-sequencing (GBS) constitutes one of the most attractive approaches for this purpose, especially in a genome as large as that of barley.
Abed, Amina, Légaré, Gaétan, Pomerleau, Sonia, Belzile, François, St-Cyr, Jérôme, Boyle, Brian   +5 more
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Multiplexed ISSR Genotyping by Sequencing (MIG-Seq)

2023
Multiplexed inter-simple sequence repeat (ISSR) genotyping by sequencing (MIG-seq) is a simple, rapid, and inexpensive method for detecting single-nucleotide polymorphisms (SNPs) using next-generation sequencing (NGS). The advantages of MIG-seq include easy application to various species without prior genetic information. In addition, this method opens
openaire   +2 more sources