Results 41 to 50 of about 1,163,135 (344)
PLoS ONE, 2012 Advancements in next-generation sequencing technology have enabled whole genome re-sequencing in many species providing unprecedented discovery and characterization of molecular polymorphisms. There are limitations, however, to next-generation sequencing
J. Poland +3 more
semanticscholar +1 more source
Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples
Biomarker Insights, 2010 It is unclear if buccal cell samples contain sufficient human DNA with adequately sized fragments for high throughput genetic bioassays. Yet buccal cell sample collection is an attractive alternative to gathering blood samples for genetic epidemiologists
Stephanie J. Loomis +12 more
doaj +1 more source
Genotyping of Transcriptomes links somatic mutations and cell identity
Nature, 2019 Defining the transcriptomic identity of malignant cells is challenging in the absence of surface markers that distinguish cancer clones from one another, or from admixed non-neoplastic cells.
Anna S. Nam +23 more
semanticscholar +1 more source
Differentiation of Tuberculosis Strains in a Population with Mainly Beijing-family Strains
Emerging Infectious Diseases, 2006 A high prevalence of tuberculosis (TB) isolates that are genetically homogenous and from the Beijing family has been reported in Russia. To map TB transmission caused by these strains, new genotyping systems are needed.
Vladyslav Nikolayevskyy +5 more
doaj +1 more source
mSystems, 2021 Q (query) fever is an infectious zoonotic disease caused by the Gram-negative bacterium Coxiella burnetii. Although the disease has been studied for decades, it still represents a threat due to sporadic outbreaks across farms in Europe.
Akinyemi M. Fasemore +6 more
doaj +1 more source
CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping
Frontiers in Pharmacology, 2016 TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and
Amanda K Riffel +10 more
doaj +1 more source
Microorganisms, 2020 In recent decades, the incidence and prevalence of nontuberculous mycobacteria (NTM) have greatly increased, becoming a major worldwide public health problem.
Jeong-Ih Shin +2 more
doaj +1 more source
Prioritizing animals for dense genotyping in order to impute missing genotypes of sparsely genotyped animals [PDF]
Genetics Selection Evolution, 2014 Genotyping accounts for a substantial part of the cost of genomic selection (GS). Using both dense and sparse SNP chips, together with imputation of missing genotypes, can reduce these costs. The aim of this study was to identify the set of candidates that are most important for dense genotyping, when they are used to impute the genotypes of sparsely ...
Yu, Xijiang +2 more
openaire +5 more sources
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source