Results 41 to 50 of about 181,932 (222)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Anderson Localization, Non-linearity and Stable Genetic Diversity [PDF]

, 2006
In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and mutation. Mutation operates as a generalized diffusion process on genotype space.
arxiv   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Use of DNA Markers for Grape Phylloxera Population and Evolutionary Genetics: From RAPDs to SSRs and Beyond

Insects, 2019
Grape phylloxera (Daktulosphaira vitifoliae Fitch) is a major pest of cultivated grapevines (Vitis spp.), occurring in virtually all viticultural regions around the world.
Javier Tello, Astrid Forneck
doaj   +1 more source

Genotyping Reveals High Clonal Diversity and Widespread Genotypes of Candida Causing Candidemia at Distant Geographical Areas

Frontiers in Cellular and Infection Microbiology, 2020
The objectives of this study were to gain further insight on Candida genotype distribution and percentage of clustered isolates between hospitals and to identify potential clusters involving different hospitals and cities. We aim to genotype Candida spp.
Jesús Guinea, Jesús Guinea, Jesús Guinea, Maiken C. Arendrup, Maiken C. Arendrup, Maiken C. Arendrup, Rafael Cantón, Rafael Cantón, Emilia Cantón, Julio García-Rodríguez, Ana Gómez, Ana Gómez, Elia Gómez G. de la Pedrosa, Rasmus K. Hare, Beatriz Orden, Maurizio Sanguinetti, Javier Pemán, Javier Pemán, Brunella Posteraro, Alba Ruiz-Gaitán, Gabriella Parisi, Daniel Archimedes Da Matta, Arnaldo L. Colombo, Carlos Sánchez-Carrillo, Carlos Sánchez-Carrillo, Carlos Sánchez-Carrillo, Elena Reigadas, Elena Reigadas, Elena Reigadas, Patricia Muñoz, Patricia Muñoz, Patricia Muñoz, Patricia Muñoz, Pilar Escribano, Pilar Escribano   +34 more
doaj   +1 more source

Evolutionary dynamics of the most populated genotype on rugged fitness landscapes [PDF]

Phys. Rev. E 76, 031922 (2007), 2007
We consider an asexual population evolving on rugged fitness landscapes which are defined on the multi-dimensional genotypic space and have many local optima. We track the most populated genotype as it changes when the population jumps from a fitness peak to a better one during the process of adaptation.
arxiv   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Genetically Independent Tetranucleotide to Hexanucleotide Core Motif SSR Markers for Identifying Lentinula edodes Cultivars

Mycobiology, 2019
For the purpose of protecting the rights of Lentinula edodes breeders, we developed a new simple sequence repeat (SSR) marker set consisting only of genetically independent tetranucleotide or longer core motifs.
Teruaki Saito, Genki Sakuta, Hitoshi Kobayashi, Kenji Ouchi, Satoshi Inatomi   +4 more
doaj   +1 more source

Genetic Analysis of African Swine Fever Virus From the 2018 Outbreak in South-Eastern Burundi

Frontiers in Veterinary Science, 2020
African swine fever (ASF) is a contagious viral disease that causes high mortality, approaching 100%, in domestic pigs and wild boars. The disease has neither a cure nor a vaccine, and it is caused by an ASF virus (ASFV), the only member of the family ...
Jean N. Hakizimana, Jean N. Hakizimana, Lionel Nyabongo, Jean B. Ntirandekura, Clara Yona, Clara Yona, Désiré Ntakirutimana, Olivier Kamana, Olivier Kamana, Hans Nauwynck, Gerald Misinzo, Gerald Misinzo   +11 more
doaj   +1 more source

Zoonotic Rickettsia Species in Small Ruminant Ticks From Tunisia

Frontiers in Veterinary Science, 2021
Tick-borne rickettsioses present a significant public health threat among emerging tick-borne diseases. In Tunisia, little is known about tick-borne Rickettsia pathogens.
Hanène Belkahia, Rachid Selmi, Rachid Selmi, Sayed Zamiti, Monia Daaloul-Jedidi, Lilia Messadi, Mourad Ben Said, Mourad Ben Said   +7 more
doaj   +1 more source