Results 41 to 50 of about 783,438 (323)

Genetic Screening to Identify Candidate Resistance Alleles to Cry1F Corn in Fall Armyworm Using Targeted Sequencing

Insects, 2021
Evolution of practical resistance is the main threat to the sustainability of transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt crops).
Katrina Schlum, Kurt Lamour, Peter Tandy, Scott J. Emrich, Caroline Placidi de Bortoli, Tejas Rao, Diego M. Viteri Dillon, Angela M. Linares-Ramirez, Juan Luis Jurat-Fuentes   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Species Distribution, Antifungal Susceptibility, and Molecular Epidemiology of Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand

Journal of Fungi, 2021
Candida species represent a common cause of bloodstream infection (BSI). Given the emergence of non-albicans Candida (NAC) associated with treatment failure, investigations into the species distribution, fungal susceptibility profile, and molecular ...
Siriphan Boonsilp, Anchalee Homkaew, Uraporn Phumisantiphong, Daranee Nutalai, Thanwa Wongsuk   +4 more
doaj   +1 more source

CIN2+ detection of the HPV DNA Array genotyping assay in comparison with the Cobas 4800 HPV test and cytology [PDF]

, 2019
BACKGROUND: HPV DNA Array is an E1-targeting PCR genotyping test, with capability of distinguishing 18 high-risk (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) and 11 low-risk HPV types (6, 11, 40, 42, 44, 54, 67, 69, 70, 85 ...
Agorastos, Theodoros, Chatzistamatiou, Kimon, Hempel, Matthias, Kaufmann, Andreas M., Krings, Amrei, Pesic, Aleksandra, Preyer, Rosemarie   +6 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Pan-cancer prevalence, risk, and clinical and demographic characteristics of Lynch Syndrome-associated variants in BioBank Japan

Communications Medicine
Background Although germline testing for DNA mismatch repair (MMR) genes is routinely performed, clinical guidelines highlight evidence gaps due to limited populations and biases.
Keijiro Mizukami, Yoshiaki Usui, Yusuke Iwasaki, Kouya Shiraishi, Makoto Hirata, Yoichiro Kamatani, Mikiko Endo, Satoshi Takahashi, Yoshiki Mochizuki, Mitusyo Yamaguchi, Takashi Kohno, Koichi Matsuda, Kokichi Sugano, Teruhiko Yoshida, Hidewaki Nakagawa, Chikashi Terao, Yuriko N. Koyanagi, Keitaro Matsuo, Yoshinori Murakami, Amanda B. Spurdle, Yukihide Momozawa   +20 more
doaj   +1 more source

Inaccurate Multilocus Sequence Typing of Acinetobacter baumannii

Emerging Infectious Diseases, 2019
Multilocus sequence typing has been useful for genotyping pathogens in surveillance and epidemiologic studies. However, it cannot reflect the true relationships of isolates for species with very dynamic genomes.
Santiago Castillo-Ramírez, Lucía Graña-Miraglia   +1 more
doaj   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

High-Throughput Sequencing Strategy for Microsatellite Genotyping Using Neotropical Fish as a Model

Frontiers in Genetics, 2018
Genetic diversity and population studies are essential for conservation and wildlife management programs. However, monitoring requires the analysis of multiple loci from many samples. These processes can be laborious and expensive.
Juliana S. M. Pimentel, Anderson O. Carmo, Izinara C. Rosse, Ana P. V. Martins, Sandra Ludwig, Susanne Facchin, Adriana H. Pereira, Pedro F. P. Brandão-Dias, Nazaré L. Abreu, Evanguedes Kalapothakis   +9 more
doaj   +1 more source