Results 61 to 70 of about 806 (159)
The secoiridoid glycoside Gentiopicroside is a USP22 inhibitor with potent antitumor immunotherapeutic activity. [PDF]
Biomed PharmacotherOver the past decade, immunotherapies have brought about significant changes in how we approach the treatment of various solid tumors and blood-related cancers. However, the effectiveness of checkpoint blockade therapy has been constrained to a rate of under 30 %. A significant challenge in the realm of tumor immunotherapy revolves around comprehending
Lu W, Chu P, Tang A, Si L, Fang D.
europepmc +3 more sources
Journal of Applied Toxicology, Volume 45, Issue 2, Page 322-338, February 2025.Abstract Despite the continued clinical application of traditional herbal medicines, scientific evidence such as toxicological safety profile of Yongdamsagan‐tang water extract (YSTW) has not yet been established. The purpose of this study was to investigate the potential toxicity profile of YSTW following a 13‐week repeated oral administration at ...
Woo‐Young Jeon +5 more
wiley +1 more source
A Highly Efficient and User‐Friendly Sensitive Skin Model on the Forearm
Journal of Cosmetic Dermatology, Volume 24, Issue 1, January 2025.ABSTRACT Background Sensitive skin is a worldwide skin problem, and its assessment of therapeutic efficacy traditionally relies on the facial stinging test. However, this test possesses certain limitations due to its restrictive application site, intense pain sensation, and adverse effects on physical appearance.
Jianhua Zhang +4 more
wiley +1 more source
Herbal Amara extract induces gastric fundus relaxation via inhibition of the M2 muscarinic receptor
Neurogastroenterology &Motility, Volume 37, Issue 1, January 2025.This preclinical study demonstrates the relaxant effect of Amara herbal extract (containing nine different plant extracts) on fundus smooth muscles dissected from guinea pigs. This relaxant effect occurs via inhibition of M2 muscarinic receptor activity.
Maria‐Riera Piqué‐Borràs +2 more
wiley +1 more source
Journal of Analytical Methods in Chemistry, 2017 Gentiana rigescens Franch (Gentianaceae) is a famous medicinal plant for treatments of rheumatism, convulsion, and jaundice. Comprehensive investigation of different parts and cultivation years of this plant has not yet been conducted.
Lu-Ming Qi +5 more
doaj +1 more source
Molecules, 2017 Gentiana rigescens is a precious herbal medicine in China because of its liver-protective and choleretic effects. A method for the qualitative identification and quantitative evaluation of G.
Zhe Wu +3 more
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Clinical and Experimental HypertensionIntroduction PCOS is a common endocrine disorder with elevated cardiometabolic risk, yet the role of the renin-angiotensin system (RAS)–iron metabolism axis in this comorbidity remains unclear.
Sihan Zhang +5 more
doaj +1 more source
Natural Product Communications, 2017 Based on NOE experiments, the structure of naphthodipyranodione from Gentianaceae plants was revised to 1,2-dihydro-4 H ,6 H ,8 H -naphto[1,2-d:4,5-c'd']dipyrano-4,8-dione.
Mikio Fujii +6 more
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Results in ChemistryThis study describes the extraction efficiency of loganic acid and gentiopicroside from Gentianae radix et rhizoma using the deep eutectic solvent-based ultrasound-assisted extraction (DES-UAE) method.
Xiaolin Tang +4 more
doaj +1 more source
Scientific ReportsThis study investigates the potential treatment of breast cancer utilizing Gentiana robusta King ex Hook. f. (QJ) through an integrated approach involving network pharmacology, molecular docking, and molecular dynamics simulation.
Bo Xiong +5 more
doaj +1 more source