Results 171 to 180 of about 5,161 (196)

Expression of glycine receptors and gephyrin in the rat cochlea

Histochemistry and Cell Biology, 2008
The cochlear efferent feedback system exerts direct impact on cochlear nerve activity and balances interaural sensitivity. So far, acetylcholine, GABA and dopamine are known to be transmitters of the inhibitory efferent system. Despite the wealth of information about glycinergic neurotransmission in the central auditory system, the inhibitory glycine ...
Julia, Dlugaiczyk, Wibke, Singer, Bernhard, Schick, Heinrich, Iro, Kristina, Becker, Cord-Michael, Becker, Ulrike, Zimmermann, Karin, Rohbock, Marlies, Knipper   +8 more
openaire   +2 more sources

Distribution of gephyrin in the human brain: an immunohistochemical analysis

Neuroscience, 2003
Gephyrin is an ubiquitously expressed protein that, in the central nervous system, generates a protein scaffold to anchor inhibitory neurotransmitter receptors in the postsynaptic membrane. It was first identified as a protein component of the glycine receptor complex.
H J, Waldvogel, K, Baer, R G, Snell, M J, During, R L M, Faull, M I, Rees   +5 more
openaire   +2 more sources

Gephyrin-Independent Clustering of Postsynaptic GABAA Receptor Subtypes

Molecular and Cellular Neuroscience, 2001
Gephyrin has been shown to be essential for the synaptic localization of the inhibitory glycine receptor and major GABA(A) receptor (GABA(A)R) subtypes. However, in retina certain GABA(A)R subunits are found at synaptic sites in the absence of gephyrin.
M, Kneussel, J H, Brandstätter, B, Gasnier, G, Feng, J R, Sanes, H, Betz   +5 more
openaire   +2 more sources

Gephyrin: a key regulatory protein of inhibitory synapses and beyond

Histochemistry and Cell Biology, 2018
Scaffolding proteins underlying postsynaptic membrane specializations are important structural and functional components of both excitatory and inhibitory synapses. At inhibitory synapses, gephyrin was identified as anchoring protein. Gephyrin self-assembles into a complex flat submembranous lattice that slows the lateral mobility of glycine and GABAA ...
Jochen Kuhse, Joachim Kirsch, Ralph Nawrotzki   +2 more
exaly   +3 more sources

Complex Interaction of the MoeA-N and MoeA-C Domains of Gephyrin Is Required for the Immortalization Activity of MLL-Gephyrin.

Blood, 2006
Abstract More than 40 proteins have been identified as partners of MLL in acute leukemia. The partner proteins are categorized based on their subcellular localization into either the nucleus or cytoplasm. Recent studies have proposed that the mechanism of transformation of MLL-cytoplasmic protein fusion products is mediated by the ...
Toshihiko Imamura, Roger T. Luo, Michael J. Thirman   +2 more
openaire   +1 more source

Gephyrin in Alzheimer's disease

2008
"Gephyrin," derived from the Greek word meaning "bridge", binds inhibitory glycine and GABAA receptors to the subsynaptic cytoskeletal elements, serving as an important receptor-microtubule linker for the assembly and stabilisation of inhibitory post-synaptic terminals in the central nervous system.
Agarwal, S., Tannenberg, R. K., Dodd, P. R.   +2 more
openaire   +2 more sources

Gephyrin

2006
openaire   +2 more sources

Gephyrin

2016
Yuan-Chen Tsai, Shiva K. Tyagarajan
openaire   +1 more source

Postsynaptic Colocalization of Gephyrin and GABA_A Receptors

Annals of the New York Academy of Sciences, 1999
SASSOE' POGNETTO, Marco, GIUSTETTO, Maurizio, PANZANELLI, Patrizia, CANTINO, Dario, J. KIRSCH, J. M. FRITSCHY   +5 more
openaire   +3 more sources

Gephyrin: ein Ankerprotein für Neurotransmitterrezeptoren

e-Neuroforum, 1995
Joachim Kirsch, Heinrich Betz
openaire   +1 more source