Results 131 to 140 of about 797 (162)
Some of the next articles are maybe not open access.
Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression
Bioorganic and Medicinal Chemistry Letters, 2013In our previous studies, geraniin was reported to have a preventive effect in the rat model of tretinoin-induced osteoporosis. However, whether geraniin exhibits an inhibitory effect on bone resorption or on MMP-9 expression is not yet known. We present here our novel findings from in vitro experiments that geraniin (a) decreases the number of mature ...
Shude Li, , Peng Chen
exaly +3 more sources
Identification of the ellagitannin geraniin as a novel Hsp90 inhibitor
Planta Medica, 2013Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone assisting the proper protein folding and assembly, and targeting misfolded proteins to the proteolytic degradation.1 - 3 Inhibition of the Hsp90 activity incapacitates simultaneously multiple client proteins, resulting in a blockade of multiple signaling pathways and, ultimately ...
A. Vassallo +5 more
openaire +3 more sources
2017
Geraniin has been credited with a range of bioactive properties and therefore merits greater research into its potential pharmaceutical, nutraceutical and cosmetic applications. To clarify its functionalities and to explore future applications, a more comprehensive understanding of geraniin; its physiochemical, permeability, bioavailability and ...
openaire +1 more source
Geraniin has been credited with a range of bioactive properties and therefore merits greater research into its potential pharmaceutical, nutraceutical and cosmetic applications. To clarify its functionalities and to explore future applications, a more comprehensive understanding of geraniin; its physiochemical, permeability, bioavailability and ...
openaire +1 more source
Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury
The American Journal of Chinese Medicine, 2017Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var.
So Jin, Bing +7 more
openaire +2 more sources
Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats
Bioorganic and Medicinal Chemistry Letters, 2015In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal ...
Shude Li, Yu Yun
exaly +3 more sources
Abstract B173: Inhibition of the Mdm2-p53 interaction by geraniin.
Molecular Cancer Therapeutics, 2011Abstract Damage by UV, IR, chemical agents and other stresses causes cell cycle arrest and induces DNA repair in eukaryotic cells while severe DNA damage invokes apoptosis. Cell cycle checkpoint signaling pathways are responsible for cell cycle arrest and decisions about cell survival or apoptosis.
Daisuke Tatsuda +4 more
openaire +1 more source
Induction of P53 genes in human hepatoma cells by Geraniin
2010 3rd International Conference on Biomedical Engineering and Informatics, 2010Aim: To study the effect of Geraniin on the expression of P53 genes in human hepatoma HepG2 cells. Methods: Cell survival was measured using MTT metabolic viability assay. Apoptosis of HepG2 was investigated by DNA gel electrophore; The level of P53 gene expression was measured by reverse transcription polymerase chain reaction (RT-PCR) and Western ...
Zhe Xiong Jin, Bao Qing Wang
openaire +1 more source
Induction of apoptosis in human gastric carcinoma cell by Geraniin
2010 3rd International Conference on Biomedical Engineering and Informatics, 2010Aim: To study the anti-tumour effect of Geraniin isolated from Agrimonia pilosa ledeb. Methods: MTT was used to study anti-tumor effect of Geraniin in vitro. Morphological observation of the cells was completed by fluorescence microscope. The effect of Gerannin on cell apoptosis in human gastric carcinoma SGC-7901 cells was studied by flow cytometry ...
Bao Qing Wang, Zhe Xiong Jin
openaire +1 more source
Geraniin: A dietary ellagitannin as a modulator of signalling pathways in cancer progression
FitoterapiaCancer remains a global health challenge, necessitating the exploration of novel therapeutic agents. Current treatment options are unable to overwhelm and cure the cancer burden. Hence, identifying new bioactive molecular entities with potent anticancer activity is the need of the hour.
Naresh Narayanan, Prabakaran +3 more
openaire +2 more sources
In Vitro BACE1 Inhibitory Activity of Geraniin and Corilagin from Geranium thunbergii
Planta Medica, 2013Generation of amyloid β peptide through the proteolytic process of amyloid precursor protein by β-secretase and γ-secretase is a main casual factor of Alzheimer's disease, since amyloid β peptide is a major and crucial component of senile plaques in Alzheimer's disease brains.
Kumju, Youn, Mira, Jun
openaire +2 more sources