Results 151 to 160 of about 1,020 (190)
Identification of the ellagitannin geraniin as a novel Hsp90 inhibitor [PDF]
Planta Medica, 2013 Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone assisting the proper protein folding and assembly, and targeting misfolded proteins to the proteolytic degradation.1 - 3 Inhibition of the Hsp90 activity incapacitates simultaneously multiple client proteins, resulting in a blockade of multiple signaling pathways and, ultimately ...
A. Vassallo +5 more
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An isobolographic analysis of the anti-nociceptive effect of geraniin in combination with morphine or diclofenac [PDF]
Journal of Basic and Clinical Physiology and Pharmacology, 2017 Abstract Background: Geraniin, a dehydroellagitannin, is a major component of the aqueous extract of the aerial parts of Phyllanthus muellerianus (Kuntze) Exell.
Eric, Boakye-Gyasi +6 more
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Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo
Bioorganic and Medicinal Chemistry Letters, 2012Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic.
Yajun Yang, Lianfeng Zhang, Chuan Qin
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Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression
Bioorganic and Medicinal Chemistry Letters, 2013In our previous studies, geraniin was reported to have a preventive effect in the rat model of tretinoin-induced osteoporosis. However, whether geraniin exhibits an inhibitory effect on bone resorption or on MMP-9 expression is not yet known. We present here our novel findings from in vitro experiments that geraniin (a) decreases the number of mature ...
, Shude Li, Peng Chen
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Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats
Bioorganic and Medicinal Chemistry Letters, 2015In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal ...
Renhua Yang, Shude Li, Yu Yun
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Effects of Geraniin on Morphology and Function of Macrophages
International Archives of Allergy and Applied Immunology, 2009The effects of geraniin, a tannin, isolated from Geranium thunbergii Sieb. et Zucc. on the morphology and function of macrophages were studied. Geraniin caused a marked retardation of the recovery from fully spread surface membrane and a highly reorganized cytoskeleton of macrophages, whereas endocytotic activity, phagocytosis and pinocytosis in the ...
Y, Ushio, T, Okuda, H, Abe
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Antiosteoporosis effect of geraniin on ovariectomy‐induced osteoporosis in experimental rats
Journal of Biochemical and Molecular Toxicology, 2021AbstractOsteoporosis is a skeletal condition that is characterized by decreasing bone density and deteriorating bone mass. The plant‐based phytoconstituent such as geraniin possesses better therapeutic potentials in biomedical field. In the current experimental study, we planned to scrutinize the therapeutic potential of geraniin against ovariectomy ...
Xiuhui Wang +7 more
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Perspectives on geraniin, a multifunctional natural bioactive compound
Trends in Food Science & Technology, 2015Ellagitannins have shown many health benefits, yet knowledge and application of these compounds are seriously limited due to their complexity and diversity. In this review, we discuss the natural occurrence and spectrum of health benefits of the ellagitannin geraniin, and its potential as a functional food additive. We examine current literature on the
Asiri Perera +2 more
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ChemInform Abstract: Geraniin‐Related Ellagitannins of the Euphorbiaceae
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Takashi Yoshida +2 more
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Identification of Urinary and Intestinal Bacterial Metabolites of Ellagitannin Geraniin in Rats
Journal of Agricultural and Food Chemistry, 2007Hydrolyzable tannins, including ellagitannins, occur in foods such as berries and nuts. Various biological activities, including antioxidant, antiviral, and antitumor activities, have been noted and reported for ellagitannins, but the absorption and metabolism of purified ellagitannins are poorly understood.
Hideyuki, Ito +2 more
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