Results 111 to 120 of about 24,196 (383)

Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility

Advanced Science, EarlyView.
This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin, Xiaodian Cai, Zhanming Zhong, Tingting Li, Xinyou Chen, Wondossen Ayalew, Zhiting Xu, Chen Wei, Xiaoke Zhang, Hong Cheng, Zhenyang Zhang, Xuehua Li, Yongjie Tang, Siqian Chen, Jun Zhou, Jinglei Si, Xibo Wu, Chao Ning, Qishan Wang, Yuchun Pan, Yahui Gao, Jiaqi Li, Ying Yu, Zhe Zhang, Yunxiang Zhao, Lingzhao Fang, Zhe Zhang   +26 more
wiley   +1 more source

Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes

Reproductive Biology and Endocrinology, 2011
Background Estrogen signaling is mediated by estrogen receptor beta isoforms in normal and neoplastic human testes. Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and
Maggiolini Marcello, Giordano Francesca, Romeo Francesco, Rago Vittoria, Carpino Amalia   +4 more
doaj   +1 more source

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumour fate

bioRxiv, 2019
Embryonal carcinomas (ECs) and seminomas are testicular germ cell tumours. ECs display expression of SOX2, while seminomas display expression of SOX17. In somatic differentiation, SOX17 drives endodermal cell fate.
S. Jostes, Martin Fellermeyer, G. Merges, G. Kristiansen, D. Nettersheim, H. Schorle   +5 more
semanticscholar   +1 more source

Paediatric cancer in Malta [PDF]

, 2003
The illness we call cancer has extraordinarily diverse features including its causation, underlying pathology, clinical symptoms, therapeutic response, and outcome or chance of cure.
Calvagna, Victor
core  

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Osteolytic bone destruction resulting from relapse of a testicular tumour 23 years after inguinal orchiectomy and adjuvant chemotherapy: a case report

Journal of Medical Case Reports, 2009
Introduction Late relapse of a testicular germ cell tumour is an uncommon occurrence. We report a case of osteolytic bone metastasis appearing 23 years after the initial treatment of a metastatic testicular mixed tumour (choriocarcinoma and embryonal ...
Kalaitzis Christos, Bantis Athanasios, Tsakaldimis Georgios, Giannakopoulos Stylianos, Sivridis Efthimios, Touloupidis Stavros   +5 more
doaj   +1 more source

MPSS profiling of embryonic gonad and primordial germ cells in chicken

Physiological Genomics, 2007
The massively parallel signature sequencing (MPSS) provides a greater depth of coverage than expressed sequence tag scan or microarray and provides a comprehensive expression profile. We used the MPSS technology to uncover gene expression profiling in the early embryonic gonads and primordial germ cells (PGCs) in the chicken.
Heebal, Kim, Tae Sub, Park, Woon Kyu, Lee, Sunjin, Moon, Jin Nam, Kim, Ji Hye, Shin, Jin Gyoung, Jung, Seon Duk, Lee, Sang Hyun, Park, Kyung Je, Park, Mi A, Kim, Sang Su, Shin, Tae Min, Kim, Jungrye, Nam, Yeonkyung, Kang, Jeong Mook, Lim, Jae Yong, Han   +16 more
openaire   +3 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

Cancers, 2019
A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies.
Ratnakar Singh, Zeeshan Fazal, Andrea K. Corbet, E. Bikorimana, Jennifer C Rodriguez, Ema M Khan, Khadeeja Shahid, S. Freemantle, M. Spinella   +8 more
semanticscholar   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source