Results 141 to 150 of about 3,782,491 (387)

Regulation of the germinal center and humoral immunity by interleukin-21

Journal of Experimental Medicine, 2019
Here we review the critical and non-redundant functions of IL-21 in regulating humoral immune responses. We particularly focus on studies in natura—from individuals from inborn errors of immunity that impact on IL-21 production and/or function.
S. Tangye, Cindy S. Ma
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Cell Reports, 2017
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson   +13 more
doaj   +1 more source

Review for "BCL6 BTB‐specific inhibitor reversely represses T Cell activation, Tfh cells differentiation and germinal center reaction in vivo"

, 2021

openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Defects in germinal center selection in SLE

Frontiers in Immunology, 2015
Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and ...
Megan eWoods, Yong-Rui eZou, Anne eDavidson   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes

Scientific Reports
Germinal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li, Chengyu Yang, Jiayuan Li, Zhenya Liu, Fenfang Gong, Xiaosu Ke, Gui-Xin Ruan, Hengjun Huang   +7 more
doaj   +1 more source

Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction [PDF]

, 2018
Xin Li, Adeline Gadzinsky, Liying Gong, Haijun Tong, Virginie Calderon, Yue Li, Daisuke Kitamura, Ulf Klein, Wallace Y. Langdon, Fajian Hou, Yong-Rui Zou, Hua Gu   +11 more
openalex   +1 more source

Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis [PDF]

, 2021
René Rauschmeier, Annika Reinhardt, Charlotte Gustafsson, Vassilis Glaros, Artem V. Artemov, Reshma Taneja, Igor Adameyko, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky   +9 more
openalex   +1 more source