Results 191 to 200 of about 3,782,491 (387)

CHK1 dosage in germinal center B cells controls humoral immunity [PDF]

, 2019
Katia Schoeler, Bojana Jakic, Julia Heppke, Claudia Soratroi, Andreas Aufschnaiter, Natascha Hermann‐Kleiter, Andreas Villunger, Verena Labi   +7 more
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Development of ADA Against Recombinant Human Interferon Beta in Immune Tolerant Mice Requires Rapid Recruitment of CD4+ T Cells, Induces Formation of Germinal Centers but Lacks Susceptibility for (Most) Adjuvants [PDF]

, 2014
Grzegorz Kijanka, Melody Sauerborn, Louis Boon, Huub Schellekens, Vera Brinks   +4 more
openalex   +1 more source

The ubiquitin ligase Itch skews light zone selection in germinal centers [PDF]

, 2023
Lindsay Renshaw, Peter Kim, Macaul Crici, Hossein Fazelinia, Lynn A. Spruce, Paula M. Oliver, Emily K. Moser   +6 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Epigenetic suppression of SLFN11 in germinal center B cells in the process of the dynamic expression change during B-cell development [PDF]

, 2020
Fumiya Moribe, Momoko Nishikori, Hiroyuki Sasanuma, Remi Akagawa, Hiroshi Arima, Shunichi Takeda, Akifumi Takaori‐Kondo, Junko Murai   +7 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cellular factors that impair the germinal center in advanced age [PDF]

William S. Foster, Edith Marcial‐Juárez, Michelle A. Linterman   +2 more
openalex   +1 more source

P009/O22 Transcriptomics unveils unique biological profile of tertiary lymphoid structures germinal centers [PDF]

, 2019
Serena Colafrancesco, Elena Pipi, Joana Campos, Saba Nayar, Valentina Iannizzotto, Roberta Priori, Guido Valesini, Benjamin A. Fisher, Francesca Barone   +8 more
openalex   +1 more source