Results 31 to 40 of about 55,936 (260)

TLR7 influences germinal center selection in murine SLE. [PDF]

PLoS ONE, 2015
TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB.
Alexis Boneparth, Weiqing Huang, Ramalingam Bethunaickan, Megan Woods, Ranjit Sahu, Shitij Arora, Meredith Akerman, Martin Lesser, Anne Davidson   +8 more
doaj   +1 more source

Germinal center reutilization by newly activated B cells [PDF]

Journal of Experimental Medicine, 2009
Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and ...
Schwickert, Tanja A, Alabyev, Boris, Manser, Tim, Nussenzweig, Michel C   +3 more
openaire   +2 more sources

Haplosufficiency of MHCII in autoreactive germinal center B cells

European Journal of Immunology, 2023
Utilizing an autoimmune bone marrow chimera model we determined that B cells depend critically on MHCII expression for participation in the germinal center, but cells displaying a 50% reduction in surface MHCII compete efficiently with their wild-type counterparts. This provides insights into the requirements for germinal center participation.
Cecilia Fahlquist‐Hagert, Thomas R. Wittenborn, Alexey Ferapontov, Lisbeth Jensen, Ewa Terczyńska‐Dyla, Søren E. Degn   +5 more
openaire   +2 more sources

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection

mBio
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis.
Erika R. Johansen, Xander G. Bradeen, Emily V. Xie, Bonnie N. Dittel, Elizabeth A. Leadbetter, Vera L. Tarakanova   +5 more
doaj   +1 more source

B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection

Journal of Virology
The human-specific gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus infect >95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas.
Sheikh Tahir Majeed, Nicholas P. Huss, Samantha M. Bradford, Christopher N. Jondle   +3 more
doaj   +1 more source

Induced Germinal Center B Cell Culture System [PDF]

BIO-PROTOCOL, 2019
The germinal center (GC) is the site where B cells undergo clonal expansion, affinity-based selection, and differentiation into memory B cells or plasma cells. It has been difficult to elucidate regulatory mechanisms for the dynamic GC B cell maturation and differentiation, partly because experimental manipulation of GC B cells in vivo has been limited
Kei Haniuda, Daisuke Kitamura
openaire   +3 more sources

The germinal center antibody response in health and disease [version 1; referees: 2 approved]

F1000Research, 2016
The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic
Anthony L. DeFranco
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

The unusual metabolism of germinal center B cells

Trends in Immunology
In the germinal center (GC), B cells undergo rounds of somatic hypermutation (SHM), proliferation, and positive selection to develop into high-affinity, long-lived plasma cells and memory B cells. It is well established that, upon activation, B cells significantly alter their metabolism, but until recently little was understood about their metabolism ...
Caitlin J. Gracie, Robert Mitchell, Julia C. Johnstone, Alexander J. Clarke   +3 more
openaire   +2 more sources

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source