Results 21 to 30 of about 55,936 (260)

Id3 Orchestrates Germinal Center B Cell Development [PDF]

Molecular and Cellular Biology, 2016
Previous studies have demonstrated that E proteins induce activation-induced deaminase (AID) expression in activated B cells. Here, we examined the role of Id3 in germinal center (GC) cells. We found that Id3 expression is high in follicular B lineage cells but declines in GC cells.
Shuwen, Chen, Masaki, Miyazaki, Vivek, Chandra, Kathleen M, Fisch, Aaron N, Chang, Cornelis, Murre   +5 more
openaire   +2 more sources

Potential role of hypoxia in early stages of Hodgkin lymphoma pathogenesis

Haematologica, 2015
A unique feature of the germinal center B cell-derived Hodgkin and Reed/Sternberg cells of classical Hodgkin lymphoma is their lost B cell phenotype and the aberrant expression of factors of other hematopoietic cell types, including ID2 and NOTCH1.
Frederik Wein, Teresa Otto, Pascal Lambertz, Joachim Fandrey, Martin-Leo Hansmann, Ralf Küppers   +5 more
doaj   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source

B Cells Hit a Class Ceiling in the Germinal Center [PDF]

Immunity, 2019
Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR; instead, CSR predominantly occurs early post immunization and declines during germinal center formation.
Lucy, Cooper, Kim L, Good-Jacobson
openaire   +2 more sources

Asymmetric B Cell Division in the Germinal Center Reaction [PDF]

Science, 2012
Stochastic or Asymmetric Fate Determination? During an adaptive immune response, B lymphocytes rapidly divide and differentiate into effector cell populations, including antibody-secreting plasmablasts and memory B cells.
Burton E, Barnett, Maria L, Ciocca, Radhika, Goenka, Lisa G, Barnett, Junmin, Wu, Terri M, Laufer, Janis K, Burkhardt, Michael P, Cancro, Steven L, Reiner   +8 more
openaire   +2 more sources

Shining a Light on Germinal Center B Cells [PDF]

Cell, 2010
The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora et al. (2010) use imaging of photoactivatable green fluorescent protein to define the movements of B cells in germinal centers and provide evidence that antibody affinity maturation is driven by competition for T cell help.
openaire   +2 more sources

B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses

BMC Immunology, 2012
Background The ICOS-B7h costimulatory receptor-ligand pair is required for germinal center formation, the production of isotype-switched antibodies, and antibody affinity maturation in response to T cell-dependent antigens.
Larimore Kevin, Liang Linda, Bakkour Sonia, Sha William C   +3 more
doaj   +1 more source

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Cell Reports, 2017
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson   +13 more
doaj   +1 more source

Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population

Frontiers in Immunology, 2021
Integrin regulation by Rap1 is indispensable for lymphocyte recirculation. In mice having B-cell-specific Rap1a/b double knockouts (DKO), the number of B cells in lymph nodes decreased to approximately 4% of that of control mice, and B cells were present
Sayaka Ishihara, Tsuyoshi Sato, Risa Sugioka, Ryota Miwa, Haruka Saito, Ryota Sato, Hidehiro Fukuyama, Akihiko Nakajima, Satoshi Sawai, Ai Kotani, Koko Katagiri   +10 more
doaj   +1 more source

B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir

Journal of Virology
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova   +3 more
doaj   +1 more source