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A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]
PLoS ONE, 2018 A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
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Regulation of germinal center B‐cell differentiation [PDF]
Immunological Reviews, 2016 SummaryGerminal centers (GC) are the main sites where antigen‐activated B‐cell clones expand and undergo immunoglobulin gene hypermutation and selection. Iterations of this process will lead to affinity maturation, replicating Darwinian evolution on the cellular level.
Zhang, Yang +2 more
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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
The Journal of Clinical Investigation, 2022 The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola +16 more
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Autoimmunity, 2012 Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions produce high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary for the host's defense against invading pathogens. This process of GC formation is reliant on the activation of antigen-specific B-cells by T-cells capable of recognizing ...
Keith M, Hamel +2 more
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Frontiers in Immunology, 2021 Germinal centers play a key role in the adaptive immune system since they are able to produce memory B cells and plasma cells that produce high affinity antibodies for an effective immune protection.
Elena Merino Tejero +14 more
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Germinal-Center B Cells in the Zone [PDF]
Immunity, 2007 Visualization of lymphocyte dynamics in vivo has only recently become feasible. In this issue of Immunity, Hauser et al. (2007) gaze into the germinal-center reaction and find B cells making some unexpected moves.
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Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses
Cell Reports, 2020 Summary: Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate ...
Bénédict Fallet +14 more
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Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. [PDF]
PLoS Pathogens, 2015 The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice also leads to life-long infection in ...
Christopher M Collins, Samuel H Speck
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A Theory of Germinal Center B Cell Selection, Division, and Exit
Cell Reports, 2012 High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann +5 more
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Transcriptional analysis of the B cell germinal center reaction [PDF]
Proceedings of the National Academy of Sciences, 2003 The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during GC transit (naïve B cells → centroblasts → centrocytes → memory B cells) by gene expression profiling.
Ulf, Klein +8 more
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