Results 1 to 10 of about 55,936 (260)

Biology of Germinal Center B Cells Relating to Lymphomagenesis [PDF]

HemaSphere, 2021
The germinal center (GC) reaction is a key feature of adaptive humoral immunity. GCs represent the site where mature B cells refine their B-cell receptor (BCR) and are selected based on the newly acquired affinity for the antigen.
Katia Basso
doaj   +4 more sources

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study [PDF]

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +2 more sources

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells [PDF]

Viruses, 2022
Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao, Masaaki Miyazawa   +8 more
doaj   +2 more sources

YY1 Is Required for Germinal Center B Cell Development. [PDF]

PLoS ONE, 2016
YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee, Vishal Sindhava, Raja Vuyyuru, Vibha Jha, Suchita Hodewadekar, Tim Manser, Michael L Atchison   +6 more
doaj   +4 more sources

Altered Germinal-Center Metabolism in B Cells in Autoimmunity [PDF]

Metabolites, 2022
B lymphocytes play an important role in the pathophysiology of many autoimmune disorders by producing autoantibodies, secreting cytokines, and presenting antigens. B cells undergo extreme physiological changes as they develop and differentiate.
Ashton K. Shiraz, Eric J. Panther, Christopher M. Reilly   +2 more
doaj   +4 more sources

Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation [PDF]

Frontiers in Immunology, 2021
B cell affinity maturation occurs in the germinal center (GC). Light-zone (LZ) GC B cells (BGC-cells) interact with follicular dendritic cells (FDCs) and compete for the limited, sequential help from T follicular helper cells needed to escape from ...
Kathleen Santamaria, Fabienne Desmots, Fabienne Desmots, Simon Leonard, Simon Leonard, Gersende Caron, Gersende Caron, Marion Haas, Marion Haas, Céline Delaloy, Fabrice Chatonnet, Fabrice Chatonnet, Delphine Rossille, Delphine Rossille, Amandine Pignarre, Amandine Pignarre, Céline Monvoisin, Marine Seffals, Claire Lamaison, Michel Cogné, Michel Cogné, Karin Tarte, Karin Tarte, Thierry Fest, Thierry Fest   +24 more
doaj   +2 more sources

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Cell Reports, 2019
Summary: Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells.
Cees E. van der Poel, Goran Bajic, Charles W. Macaulay, Theo van den Broek, Christian D. Ellson, Gerben Bouma, Gabriel D. Victora, Søren E. Degn, Michael C. Carroll   +8 more
doaj   +3 more sources

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. [PDF]

J Exp Med, 2021
Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD.   +12 more
europepmc   +2 more sources

Germinal Center B Cell Dynamics [PDF]

Immunity, 2016
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation.
Luka, Mesin, Jonatan, Ersching, Gabriel D, Victora   +2 more
openaire   +2 more sources

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source