Results 91 to 100 of about 214,576 (214)
Adherence and persistence with direct oral anticoagulants by dose regimen: A systematic review
British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 1096-1113, April 2025.Introduction Direct oral anticoagulants (DOACs) are used in patients with non‐valvular atrial fibrillation (NVAF) to prevent complications such as embolic events. Poor adherence to DOACs increases the risk of these complications. This manuscript reviews the impact of once‐daily (OD) vs twice‐daily (BID) dosing regimens on adherence and persistence to ...
Raúl Quirós López +2 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba +9 more
wiley +1 more source
An investigation of factors associated with depression in older adults
, 1989 As the population ages, there is a need for continued research into the etiology of geriatric depression and improved ways to detect individuals at risk for developing this disorder.
Mayhew, Katherine Mary
core
British Journal of Clinical Pharmacology, Volume 91, Issue 5, Page 1330-1351, May 2025.Inappropriate and overuse of antimicrobials is increasing antimicrobial resistance. Understanding physicians' antimicrobial decision‐making is essential for developing interventions to optimize prescribing. The aim of this review was to identify the factors that influence physicians' antimicrobial prescribing decisions.
Savannah Reali +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Deprescribing is complex because it involves patients' health, values, and preferences. The World Health Organization and Canadian Medication Appropriateness and Deprescribing Network have recommended that deprescribing be integrated into health curricula, prompting the need for further understanding about deprescribing education.
Brian J. Chow +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Patients with severe mental disorder and diabetes may be exposed to inappropriate polypharmacy increasing the risk of side effects and drug interactions. Although medication reviews may facilitate short‐term deprescribing, they are not known to affect clinical outcomes.
Johan Frederik Mebus Meyer Christensen +2 more
wiley +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Appraising the visibility, relevance and impacts of clinical pharmacology
British Journal of Clinical Pharmacology, EarlyView.Aims Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.
Serge Cremers +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims The perspectives of patients and healthcare professionals regarding deprescribing in surgical wards within hospital settings are unknown. The aim of this study was to explore current practices, attitudes and the enablers and barriers to deprescribing in hospital for older surgical inpatients from the perspectives of doctors, pharmacists ...
Bonnie M. Liu +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang +3 more
wiley +1 more source