Results 91 to 100 of about 249,811 (339)

Putting off Tomorrow to Do What You Want Today: Planning for Retirement [PDF]

open access: yes, 2011
In this article we note that in the coming years, a larger number of people will be experiencing retirement for a longer period of time than ever before and that despite this fact, many will find themselves unprepared for this stage of their lives.
Adams, Gary A., Rau, Barbara L.
core   +2 more sources

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan   +8 more
wiley   +1 more source

Senescence can play an essential role in modelling and estimation of vector based epidemiological indicators: demographical approach [PDF]

open access: yes
In the paper basic epidemiological indicators, produced by an aging population of vectors, are calculated. In the study we follow two lines: calculations for demographically structured population and individual life-history approach.
Anatoli I. Michalski   +5 more
core  

Quality of life: Conceptual challenges in exploring the role of ICT in active ageing [PDF]

open access: yes, 2008
The chapter aims to examine the definitional challenges associated with the term quality of life, measurement challenges, the challenges associated with enhancing quality of life, and the role of information and communication technologies (ICT) in ...
Gilhooly, K, Gilhooly, M, Jones, RB
core   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

open access: yesAdvanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu   +22 more
wiley   +1 more source

Probabilistic Estimation of Human Interaction Needs in Context of a Robotic Assistance in Geriatrics

open access: yesCurrent Directions in Biomedical Engineering, 2019
The key purpose of assistance robots is to help people coping with work-related or everyday tasks. To ensure an intuitive and effective support by an assistance robot, its expectation conform behavior is essential.
Philipp Patrick   +3 more
doaj   +1 more source

Ageing, old age and media: Critical appraisal of knowledge practices in academic research

open access: yesInternational Journal of Ageing and Later Life, 2019
This interpretative literature review discusses research published between 2000 and 2015 that focuses on the media representation of older adults. The key objective is to offer a critical discussion on the knowledge and assumptions underlying such ...
Sara Mosberg Iversen, Monika Wilinska
doaj   +1 more source

Starting Well Health Visiting Practice Guides: An Independent Audit [PDF]

open access: yes, 2004
This report presents findings from a small study of the use of the health visiting practice guides developed as part of the Staring Well National Demonstration project.
Dalley, G, Gilhooly, M
core  

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

open access: yesAdvanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan   +11 more
wiley   +1 more source

An investigation of factors associated with depression in older adults

open access: yes, 1989
As the population ages, there is a need for continued research into the etiology of geriatric depression and improved ways to detect individuals at risk for developing this disorder.
Mayhew, Katherine Mary
core   +1 more source

Home - About - Disclaimer - Privacy