Results 111 to 120 of about 279,197 (333)
Advanced Science, EarlyView.This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun +15 more
wiley +1 more source
The Effect of an Aging Suit on Young and Middle-Aged Adults’ Attitudes Toward Older Adults [PDF]
, 2018 Background: Ageism, a type of discrimination based on a person’s age, can lead to negative attitudes, intolerance, and judgment towards older adults. With the increase of older adults in society, understanding the correlates of negative attitudes becomes
Allen, Kelly
core +2 more sources
Sociophysics Simulations III: Retirement Demography
, 2005 This third part of the lecture series deals with the question: Who will pay for your retirement? For Western Europe the answer may be ``nobody'', but for Algeria the demography looks more promising.Comment: For 8th Granada seminar (AIP Conf.
Stauffer, Dietrich, Zekri, Lotfi
core +1 more source
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Advanced Science, EarlyView.This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen +17 more
wiley +1 more source
Psycho-social effects of a brain-training program among healthy older adults [PDF]
, 2008 Grounded in cognitive neuroscience and social exchange theory, this research evaluated the relationship between changes in cognitive functioning and two psycho-social dimensions of life among healthy adults over the age of 70 (N=12).
Bailey, William C. +2 more
core +2 more sources
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Representation of Old Age and Pain in Iris
Nalans, 2017 Adapted for the screen by Sir Richard and Charles Wood and directed by Sir Richard Eyre, Iris tells the life story of famous British philosopher and novelist, Iris Murdoch.
Fatma Kalpaklı
doaj