Results 121 to 130 of about 249,811 (339)
Advanced Science, EarlyView.This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu +18 more
wiley +1 more source
“Listen Carefully:” A Study of Ageist Stereotypes and Undergraduates’ Desire to Work with Elders [PDF]
, 2013 “Listen Carefully:” A Study of Ageist Stereotypes and Undergraduates’ Desire to Work with Elders identifies and assesses how prior experience with elders and ageist stereotypes informs the degree to which undergraduates are inclined (or disinclined) to ...
Ilg, Genevieve
core +1 more source
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Advanced Science, EarlyView.Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie +18 more
wiley +1 more source
Gerontological Studies, Especially on Epidemiology of Hypertension
, 1960 Hiroko Date
openalex +4 more sources
Editorial: Emotion regulation and mental health in older adults
Frontiers in Psychology, 2023 Gary Christopher, David Facal
doaj +1 more source
AlzHope: A Multi-volume eBook Confidence Builder for Alzheimer’s Worriers
Nonpartisan Education Review, 2010 no ...
Robert Oliphant
doaj
European Clinical Section of The International Association of Gerontology [PDF]
, 1962 J.A.M. Schreuder
openalex +1 more source
Advanced Science, EarlyView.This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai +5 more
wiley +1 more source