Results 81 to 90 of about 279,197 (333)

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang   +9 more
wiley   +1 more source

Raising the level of medical gerontology: Evaluation of the European Academy for Medicine of Ageing course [PDF]

open access: yes, 2018
The two-year EAMA course was established in 1995 by the Group of European Professors in Medical Gerontology (GEPMG) with the aim of raising the global standard of medical gerontology in (chiefly) European junior faculties. To determine the impact of this
Michel, J-P
core  

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

open access: yesAdvanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu   +5 more
wiley   +1 more source

The discourse of ageing dynamics in contemporary US drama: definitions and representations [PDF]

open access: yes, 2015
У статті здійснюється спроба визначення літературної геронтології як міждисциплінарної галузі гуманітарного знання. Представлено робочу гіпотезу поняття вікової динаміки старіння в рамках літературної геронтології для аналізу проблемно-семантичних та ...
Гайдаш, Анна Владиславівна
core  

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

open access: yesAdvanced Healthcare Materials, EarlyView.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon   +7 more
wiley   +1 more source

„Mit 70 Jahren hat kein Mensch das Recht, sich alt zu fühlen.“ – Altersdiskurse und Bilder des Alters in der NS-Sozialpolitik

open access: yesÖsterreichische Zeitschrift für Geschichtswissenschaften, 2011
Social policies of Nazi Germany aimed directly at cutting expenses for pensions and other social security benefits for old people. In order to reduce social costs, the age of retirement was supposed to be increased through various policies.
Benjamin Möckel
doaj   +1 more source

Cell‐Stress‐Free Percutaneous Bioelectrodes

open access: yesAdvanced Materials, EarlyView.
A structurally adaptive soft microneedle bioelectrode is developed with an effervescent sacrificial core that dissolves after insertion, leaving an ultrathin and highly compliant electrode integrated with skin. This design enables ultra‐flexible, cell‐stress‐free, stable, and high‐fidelity electrophysiological monitoring under dynamic conditions such ...
Jungho Lee   +14 more
wiley   +1 more source

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project [PDF]

open access: yes, 2017
Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically defined phenotypes of the disease. Most of the clinical signs of DS are typical of the ageing process
BACALINI, MARIA GIULIA   +14 more
core   +1 more source

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity

open access: yesAdvanced Materials, EarlyView.
The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar   +7 more
wiley   +1 more source

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