Results 81 to 90 of about 249,811 (339)

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Female gerontology in TV-advertising [PDF]

Социологический журнал, 2012
The paper backgrounds the necessity of theoretical advancing the female gerontology project. Two models of female gerontology problems interpretation are considered: the model of “mail dominance” and the model of “female narcissism”.
doaj  

„Mit 70 Jahren hat kein Mensch das Recht, sich alt zu fühlen.“ – Altersdiskurse und Bilder des Alters in der NS-Sozialpolitik

Österreichische Zeitschrift für Geschichtswissenschaften, 2011
Social policies of Nazi Germany aimed directly at cutting expenses for pensions and other social security benefits for old people. In order to reduce social costs, the age of retirement was supposed to be increased through various policies.
Benjamin Möckel
doaj   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Bibliometric Analysis of microRNA: A Comprehensive Evaluation of Its Contribution to Acute Coronary Syndromes

Journal of Multidisciplinary Healthcare
Yuqian Gao,1,* Tianli Li,2,* Xiaohong Mu,1,* Xiaoxia Ren,1 Jing Wang,1 Jiasai Fan,1 Haiyan Zhu,1,3 Xian Wang1,3 1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2National ...
Gao Y, Li T, Mu X, Ren X, Wang J, Fan J, Zhu H, Wang X   +7 more
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Frailty is an independent risk factor for recurrence and mortality following curative resection of stage I–III colorectal cancer

Annals of Gastroenterological Surgery, 2020
Aim With population aging, the number of frail patients with colorectal cancer has increased. The Clinical Frailty Scale (CFS) is a validated tool for assessing frailty, and higher scores indicate worse clinical outcomes following cardiovascular ...
Kosuke Mima, Nobutomo Miyanari, Atsushi Morito, Shinsei Yumoto, Takashi Matsumoto, Keisuke Kosumi, Mitsuhiro Inoue, Takao Mizumoto, Tatsuo Kubota, Hideo Baba   +9 more
doaj   +1 more source

The discourse of ageing dynamics in contemporary US drama: definitions and representations [PDF]

, 2015
У статті здійснюється спроба визначення літературної геронтології як міждисциплінарної галузі гуманітарного знання. Представлено робочу гіпотезу поняття вікової динаміки старіння в рамках літературної геронтології для аналізу проблемно-семантичних та ...
Гайдаш, Анна Владиславівна
core  

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Características individuais e clínicas de pessoas idosas com diabetes: investigação temática em oficina sociopoética [Individuals and clinics characteristics of elderly people with diabetes: thematic research in sociopoetic workshop]

Revista Enfermagem UERJ, 2013
Este trabalho teve como objetivo delinear o perfil sociodemográfico e clínico de pessoas idosas com diabetes, visando posterior orientação para o autocuidado. Método sociopoético, na etapa de investigação temática entre um grupo pesquisador composto por
Iraci dos Santos, Renata Gomes Guerra, Leandro Andrade da Silva   +2 more
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