Orthostatic Myoclonus—Clinical and Electrophysiological Features in a Large Retrospective Cohort
Abstract Background Orthostatic myoclonus is characterized by irregular, lower limb myoclonic bursts during stance and is a major cause of postural instability and falls. However, studies are limited, and little is known about its pathophysiology. Objectives We sought to define the clinical and electrophysiological features of orthostatic myoclonus in ...
Sai A. Nagaratnam +8 more
wiley +1 more source
Relative importance of blood-based biomarkers for Alzheimer's disease-specific neurodegeneration and cognitive decline. [PDF]
Kim KY +6 more
europepmc +1 more source
Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu +9 more
wiley +1 more source
Assessment of Brain-Specific and Neuroendocrine Biomarkers for Intracerebral Hemorrhage Diagnosis: A Prospective Cohort Study. [PDF]
Apiliogullari S +11 more
europepmc +1 more source
Association Between Plasma Phosphorylated Tau‐217 and Cognition in Parkinson's Disease
Abstract Background Alzheimer's disease (AD) co‐pathology contributes to dementia in PD, but its role in earlier cognitive impairment remains uncertain. Objective To determine if p‐tau217, a biomarker of early AD, is associated with cognitive impairment in PD.
Trycia Kouchache +10 more
wiley +1 more source
Varicose projection astrocytes: Conserved reactive cells in brain pathology. [PDF]
Ciani C +32 more
europepmc +1 more source
Mutations in GFAP Alter Early Lineage Commitment of Organoids
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder.
Regenerative Medicine and Stem Cells +20 more
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GFAP-Dependent Transcriptional Dynamics and Cellular Heterogeneity in Primary, Recurrent, and Grade III Gliomas. [PDF]
Hadizadeh M, Mousavi SZ, Ghasemi S.
europepmc +1 more source
High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena +7 more
wiley +1 more source

