Dietary medium chain triglycerides impairs orexigenic action of ghrelin in mice [PDF]
Frontiers in EndocrinologyIntroductionGhrelin, a stomach-derived hormone, increases food intake and body weight. Efforts have been made therefore to modulate ghrelin signaling for the treatment of obesity or emaciation.
Daisuke Aotani +15 more
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The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype [PDF]
PeerJ, 2021 It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in ...
Patrick B. Thomas +14 more
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Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
Biomolecules, 2022 Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression.
Anuhya S. Kotta +4 more
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Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation. [PDF]
PLoS ONE, 2013 Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21
Hyung Jin Choi +11 more
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Veterinary Sciences, 2023 Appetite abnormalities and weight loss are important comorbidities in the treatment of chronic kidney disease (CKD) in cats. Ghrelin, a key hormone involved in the regulation of appetite and metabolism, is a potential marker of appetite dysregulation in ...
Katelyn Brusach +7 more
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Aquaculture Reports, 2023 Ghrelin has been well known as an orexigenic hormone that regulates appetite and energy metabolism in animals. Recent studies imply the regulatory function of ghrelin on ovary development, however, the mechanism about the effects of ghrelin on key ...
Jiamin Pi +7 more
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A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. [PDF]
PLoS ONE, 2011 The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a 23-aa (obestatin) mature peptides,
Manuel D Gahete +7 more
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A review on ghrelin and fish reproduction
Reproduction and Breeding, 2021 Ghrelin is a multifunctional peptide hormone which dominantly secreted in stomach and intestine. Ghrelin involves in growth control, food intake, energy balance, and reproductive process.
Huan Zhong, Yi Hu, Fan Yu
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“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
Molecular Metabolism, 2021 Background: The hormone ghrelin stimulates food intake, promotes adiposity, increases body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels and the functioning of other components of the broader ghrelin system have ...
Deepali Gupta +4 more
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Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells
Frontiers in Endocrinology, 2013 Background: The enzyme ghrelin O-acyltransferase (GOAT) catalyzes the acylation of ghrelin. The molecular form of GOAT, together with its reaction in vitro, has been reported previously.
Yoshihiro eNishi +8 more
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