Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens [PDF]
Frontiers in PhysiologyThe aim of this study was to evaluate the effect of the cholinergic receptor antagonists on ghrelin (GHRL) expression and release from parts of the gastrointestinal system in an unique animal model—newly hatched chickens.
Colin Guy Scanes +2 more
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The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype [PDF]
PeerJ, 2021 It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in ...
Patrick B. Thomas +14 more
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Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation. [PDF]
PLoS ONE, 2013 Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21
Hyung Jin Choi +11 more
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Veterinary Sciences, 2023 Appetite abnormalities and weight loss are important comorbidities in the treatment of chronic kidney disease (CKD) in cats. Ghrelin, a key hormone involved in the regulation of appetite and metabolism, is a potential marker of appetite dysregulation in ...
Katelyn Brusach +7 more
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Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
Biomolecules, 2022 Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression.
Anuhya S. Kotta +4 more
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A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. [PDF]
PLoS ONE, 2011 The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a 23-aa (obestatin) mature peptides,
Manuel D Gahete +7 more
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The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Molecular Cancer, 2017 Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Daniel Hormaechea-Agulla +18 more
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Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. [PDF]
PLoS ONE, 2012 The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability.
Michael M Scott +8 more
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Frontiers in Cell and Developmental Biology, 2021 The role of high-fat diet (HFD) induced gut microbiota alteration and Ghrelin as well as their correlation in benign prostatic hyperplasia (BPH) were explored in our study. The gut microbiota was analyzed by 16s rRNA sequencing.
Meng Gu +7 more
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Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells
Frontiers in Endocrinology, 2013 Background: The enzyme ghrelin O-acyltransferase (GOAT) catalyzes the acylation of ghrelin. The molecular form of GOAT, together with its reaction in vitro, has been reported previously.
Yoshihiro eNishi +8 more
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