Results 11 to 20 of about 83,620 (273)
Aquaculture Reports, 2023 Ghrelin has been well known as an orexigenic hormone that regulates appetite and energy metabolism in animals. Recent studies imply the regulatory function of ghrelin on ovary development, however, the mechanism about the effects of ghrelin on key ...
Jiamin Pi +7 more
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MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]
Journal of Molecular Endocrinology, 2013 After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya +2 more
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A review on ghrelin and fish reproduction
Reproduction and Breeding, 2021 Ghrelin is a multifunctional peptide hormone which dominantly secreted in stomach and intestine. Ghrelin involves in growth control, food intake, energy balance, and reproductive process.
Huan Zhong, Yi Hu, Fan Yu
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Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]
, 2015 BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton +42 more
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Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells
Frontiers in Endocrinology, 2013 Background: The enzyme ghrelin O-acyltransferase (GOAT) catalyzes the acylation of ghrelin. The molecular form of GOAT, together with its reaction in vitro, has been reported previously.
Yoshihiro eNishi +8 more
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“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
Molecular Metabolism, 2021 Background: The hormone ghrelin stimulates food intake, promotes adiposity, increases body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels and the functioning of other components of the broader ghrelin system have ...
Deepali Gupta +4 more
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Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]
, 2016 The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B. +8 more
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Frontiers in Cell and Developmental Biology, 2021 The role of high-fat diet (HFD) induced gut microbiota alteration and Ghrelin as well as their correlation in benign prostatic hyperplasia (BPH) were explored in our study. The gut microbiota was analyzed by 16s rRNA sequencing.
Meng Gu +7 more
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Insights from engraftable immunodeficient mouse models of hyperinsulinaemia
Scientific Reports, 2017 Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 −/−) suitable for ...
Michelle L. Maugham +11 more
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The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Molecular Cancer, 2017 Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Daniel Hormaechea-Agulla +18 more
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