Results 11 to 20 of about 30,314 (188)
International Journal of Peptides, 2010 Few peptide hormones have attracted as much attention of the scientific community as ghrelin, the natural secretagogue for growth hormone (GH) identified by M. Kojima et al. in 1999 [1], resulting in more than 4000 PubMed citations over the last ten years. The initial interest can be attributed to the ability of ghrelin to stimulate feeding in mammals,
S. O. FETISSOV +3 more
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MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]
Journal of Molecular Endocrinology, 2013 After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya +2 more
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Frontiers in Cell and Developmental Biology, 2021 The role of high-fat diet (HFD) induced gut microbiota alteration and Ghrelin as well as their correlation in benign prostatic hyperplasia (BPH) were explored in our study. The gut microbiota was analyzed by 16s rRNA sequencing.
Meng Gu +7 more
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Insights from engraftable immunodeficient mouse models of hyperinsulinaemia
Scientific Reports, 2017 Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 −/−) suitable for ...
Michelle L. Maugham +11 more
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The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Molecular Cancer, 2017 Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Daniel Hormaechea-Agulla +18 more
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Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. [PDF]
PLoS ONE, 2013 Taste perception plays an important role in regulating food preference, eating behavior and energy homeostasis. Taste perception is modulated by a variety of factors, including gastric hormones such as ghrelin. Ghrelin can regulate growth hormone release,
Huan Cai +7 more
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Different forms of ghrelin exhibit distinct biological roles in tilapia
Frontiers in Endocrinology, 2013 Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g.
Larry eRiley
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Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. [PDF]
PLoS ONE, 2012 The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability.
Michael M Scott +8 more
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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Periodontology 2000, EarlyView., 2023 Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti +2 more
wiley +1 more source
Journal of Obesity & Metabolic Syndrome, 2017 Background : Desacyl ghrelin is acylated by ghrelin O-acyltransferase (GOAT) and converted to acyl ghrelin. To date, little is known about the relationship among the levels of these two forms of ghrelin, GOAT level, and insulin resistance in Asian ...
Young Hye Cho +11 more
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