Results 11 to 20 of about 93,938 (325)

Ghrelin enhances appetite and increases food intake in humans. [PDF]

Journal of Clinical Endocrinology and Metabolism, 2001
Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans.
Bloom, SR, Brynes, AE, Cohen, MA, Dhillo, WS, Frost, GS, Ghatei, MA, Murphy, KG, Seal, LJ, Wren, AM   +8 more
core   +3 more sources

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. [PDF]

Diabetes, 2001
The recently discovered orexigenic peptide ghrelin is produced primarily by the stomach and circulates in blood at levels that increase during prolonged fasting in rats.
D. Cummings, J. Purnell, R. S. Frayo, Karin Schmidova, B. Wisse, D. Weigle   +5 more
semanticscholar   +2 more sources

Ghrelin [PDF]

Molecular Metabolism, 2015
The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.In this review, we discuss the diverse biological functions of ghrelin ...
Müller, T. D, Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., BROGLIO, Fabio, Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., GHIGO, Ezio, Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S., Dickson, S. L., Diéguez, C., GRANATA, Riccarda, Grill, H. J., Grove, K., Habegger, K. M., Heppner, K., Heiman, M. L., Holsen, L., Holst, B., Inui, A., Jansson, J. O., Kirchner, H., Korbonits, M., Laferrère, B., Leroux, C. W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez Tilve, D., Pfluger, P. T., Schwartz, T. W., Seeley, R. J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M. O., van der Lely, A. J., van der Ploeg, L. H. T., Zigman, J. M., Kojima, M., Kangawa, K., Smith, R. G., Horvath, T., Tschöp, M. H.   +56 more
openaire   +8 more sources

Circulating ghrelin levels are decreased in human obesity. [PDF]

Diabetes, 2001
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates GH secretion but also causes weight gain by increasing food intake and ...
M. Tschöp, C. Weyer, P. Tataranni, V. Devanarayan, E. Ravussin, M. Heiman   +5 more
semanticscholar   +2 more sources

The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.

Endocrinology, 2000
Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R).
A. Wren, C. Small, Helen L. Ward, K. Murphy, C. Dakin, S. Taheri, A. Kennedy, G. Roberts, D. Morgan, M. Ghatei, S. Bloom   +10 more
semanticscholar   +2 more sources

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. [PDF]

Journal of Clinical Endocrinology and Metabolism, 2002
Ghrelin is a novel growth hormone-releasing peptide, originally identified in the rat stomach as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R1a).
S. Gnanapavan, B. Kola, S. Bustin, D. Morris, Patrick McGee, P. Fairclough, S. Bhattacharya, R. Carpenter, A. Grossman, M. Korbonits   +9 more
semanticscholar   +3 more sources

Ghrelin in the human myometrium [PDF]

Reproductive Biology and Endocrinology, 2010
Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human contractility in vitro.
O'Brien, Margaret, Earley, Padraig, Morrison, John J., Smith, Terry   +3 more
openaire   +5 more sources

Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion [PDF]

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2014
Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis ...
Shilpa Gaidhane, Mahanaaz Khatib, Nazli Khatib, Padama Simkhada, Quazi Syed Zahiruddin, Abhay Gaidhane, Dilip Gode   +6 more
openaire   +4 more sources

Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. [PDF]

Journal of Clinical Endocrinology and Metabolism, 2002
Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food intake and GH secretion. We determined plasma ghrelin concentrations in patients with simple obesity, anorexia nervosa, and type 2 diabetes mellitus by RIA.
Tomomi Shiiya, M. Nakazato, M. Mizuta, Y. Date, M. S. Mondal, Muneki Tanaka, S. Nozoe, H. Hosoda, K. Kangawa, S. Matsukura   +9 more
semanticscholar   +2 more sources

The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype [PDF]

PeerJ, 2021
It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in ...
Patrick B. Thomas, Penny Jeffery, Manuel D. Gahete, Eliza Whiteside, Carina Walpole, Michelle Maugham, Lidija Jovanovic, Jennifer Gunter, Elizabeth Williams, Colleen Nelson, Adrian Herington, Raul M. Luque, Rakesh Veedu, Lisa K. Chopin, Inge Seim   +14 more
doaj   +2 more sources