Results 21 to 30 of about 93,938 (325)

GIST and Ghrelin: To Be or Not to Be? [PDF]

Diagnostics, 2021
Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46
Irene Alexandra Spiridon, Delia Gabriela Apostol Ciobanu, Simona Eliza Giușcă, Dan Ferariu, Iulia Cătălina Pleşca, Irina Draga Căruntu   +5 more
openaire   +3 more sources

Update on Ghrelin [PDF]

International Journal of Peptides, 2010
Few peptide hormones have attracted as much attention of the scientific community as ghrelin, the natural secretagogue for growth hormone (GH) identified by M. Kojima et al. in 1999 [1], resulting in more than 4000 PubMed citations over the last ten years. The initial interest can be attributed to the ability of ghrelin to stimulate feeding in mammals,
S. O. FETISSOV, LAVIANO, Alessandro, S. KALRA, A. INUI   +3 more
openaire   +3 more sources

Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens. [PDF]

Front Physiol
The aim of this study was to evaluate the effect of the cholinergic receptor antagonists on ghrelin (GHRL) expression and release from parts of the gastrointestinal system in an unique animal model—newly hatched chickens.
Scanes CG, Jaszcza K, Pierzchala-Koziec K.   +2 more
europepmc   +2 more sources

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Nature Communications, 2021
Ghrelin, also called “the hunger hormone”, is a gastric peptide hormone that regulates food intake, body weight, as well as taste sensation, reward, cognition, learning and memory.
Yue Wang, Shimeng Guo, Y. Zhuang, Ying Yun, P. Xu, Xinheng He, Jia Guo, W. Yin, H. Xu, Xin Xie, Yi Jiang   +10 more
semanticscholar   +1 more source

Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation. [PDF]

PLoS ONE, 2013
Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21
Hyung Jin Choi, Kyoung Ho Ki, Jae-Yeon Yang, Bo Young Jang, Jung Ah Song, Wook-Young Baek, Jung Hee Kim, Jee Hyun An, Sang Wan Kim, Seong Yeon Kim, Jung-Eun Kim, Chan Soo Shin   +11 more
doaj   +1 more source

Measurement of Ghrelin as a Marker of Appetite Dysregulation in Cats with and without Chronic Kidney Disease

Veterinary Sciences, 2023
Appetite abnormalities and weight loss are important comorbidities in the treatment of chronic kidney disease (CKD) in cats. Ghrelin, a key hormone involved in the regulation of appetite and metabolism, is a potential marker of appetite dysregulation in ...
Katelyn Brusach, Sarah Lorbach, Jessica Quimby, Eline Nijveldt, Rene Paschall, Hannah Kinsella, Valerie Parker, Ramiro Toribio   +7 more
doaj   +1 more source

The Role of Ghrelin and Ghrelin Signaling in Aging [PDF]

International Journal of Molecular Sciences, 2017
With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide.
Marie Amitani, Haruka Amitani, Kai-Chun Cheng, Timothy Sean Kairupan, Nanami Sameshima, Ippei Shimoshikiryo, Kimiko Mizuma, Natasya Trivena Rokot, Yasuhito Nerome, Tetsuhiro Owaki, Akihiro Asakawa, Akio Inui   +11 more
openaire   +2 more sources

Starving for Ghrelin [PDF]

Cell Metabolism, 2014
The initial discovery of ghrelin as a potent orexigenic hormone raised excitement about a new direction for possibly treating eating disorders. McFarlane et al. (2014) show that with deletion of ghrelin-producing cells from an adult animal, there is little effect on appetitive behaviors but significant implications for glucose homeostasis.
David Spanswick, Mark W. Sleeman
openaire   +3 more sources

Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression

Biomolecules, 2022
Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression.
Anuhya S. Kotta, Abigail S. Kelling, Karen A. Corleto, Yuxiang Sun, Erin D. Giles   +4 more
doaj   +1 more source

Ghrelin for cachexia [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2010
Ghrelin, a natural ligand for the growth hormone (GH)‐secretagogue receptor, is primarily produced in the stomach. Administration of ghrelin stimulates food intake and GH secretion in both animals and humans. Ghrelin is the only circulating hormone known to stimulate appetite in humans.
Takashi Akamizu, Kenji Kangawa
openaire   +3 more sources