Results 51 to 60 of about 38,787 (232)

Current status, trends, and controversies in the selection of gastrectomy procedures: Insights from two nationwide questionnaire surveys conducted over a 7‐year interval in Japan

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the evolving trends and challenges in gastrectomy procedures in Japan, drawing on two nationwide surveys conducted in 2014 and 2021. Results show a significant shift toward minimally invasive and function‐preserving surgeries, such as laparoscopic and robot‐assisted gastrectomy, with an emphasis on enhancing postoperative ...
Koji Nakada, Hideyuki Kashiwagi, Shinichi Kinami, Hiroharu Yamashita, Nobuyoshi Hanyu, Atsushi Oshio, Michio Kaminishi, Yasuyuki Seto   +7 more
wiley   +1 more source

“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

Molecular Metabolism, 2021
Background: The hormone ghrelin stimulates food intake, promotes adiposity, increases body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels and the functioning of other components of the broader ghrelin system have ...
Deepali Gupta, Sean B. Ogden, Kripa Shankar, Salil Varshney, Jeffrey M. Zigman   +4 more
doaj  

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source

Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the long‐term endocrine and metabolic consequences of ghrelin‐depleted gastrectomy, with a focus on skeletal muscle mass and bone mineral content. Sustained reductions in serum desacyl‐ghrelin were linked to lower IGF‐1 levels, resulting in significant loss of muscle and bone.
Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Naoki Hiki   +9 more
wiley   +1 more source

Ninjin'yoeito Targets Distinct Ca2+ Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus

Frontiers in Nutrition, 2020
Appetite loss or anorexia substantially deteriorates quality of life in various diseases, and stand upstream of frailty. Neuropeptide Y (NPY) in the hypothalamic arcuate nucleus (ARC) and ghrelin released from stomach are potent inducers of appetite.
Chayon Goswami, Chayon Goswami, Chayon Goswami, Chayon Goswami, Katsuya Dezaki, Katsuya Dezaki, Lei Wang, Lei Wang, Lei Wang, Akio Inui, Yutaka Seino, Yutaka Seino, Toshihiko Yada, Toshihiko Yada, Toshihiko Yada, Toshihiko Yada   +15 more
doaj   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]

Journal of Molecular Endocrinology, 2013
After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Kenji Kangawa, Mikiya Miyazato, Hiroyuki Kaiya   +2 more
openaire   +3 more sources

Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein

FEBS Open Bio, 2021
Ghrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion.
Kana Tanikawa, Kentaro Kaneko, Shimon Abe, Jyunya Nakato, Yuki Tokuyama, Sayano Odaka, Hiroshi Iwakura, Masaru Sato, Atsushi Kurabayashi, Hideyuki Suzuki, Miki Makita, Hiroyuki Ikemoto, Shigenobu Matsumura, Kazuo Inoue, Kousaku Ohinata   +14 more
doaj   +1 more source

Moderate to Vigorous Physical Activity as a Cause of Dietary Restriction in Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The mechanisms that facilitate prolonged dietary restriction in eating disorders, particularly in the absence of binge eating, remain poorly understood. The activity‐based anorexia model and basic science in exercise physiology suggest that moderate to vigorous physical activity leads to reduced energy intake relative to metabolic ...
K. Jean Forney, Angela R. Hillman, Lindsay P. Bodell   +2 more
wiley   +1 more source

Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2

International Journal of Endocrinology, 2015
To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity.
Yuki Shiimura, Hideko Ohgusu, Takahiro Sato, Masayasu Kojima   +3 more
doaj   +1 more source