Results 151 to 160 of about 3,121 (172)

Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review

Life Sciences, 2022
Growth hormone secretagogue receptor type 1A (GHSR-1A) is a functional receptor of orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that regulate incentive value of artificial reward in substance abuse. Interestingly, GHSR-1A has also shown ligand-independent constitutive activity.
Shreyasi Gupta, Sanchari Mukhopadhyay, Arkadeep Mitra   +2 more
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Molecular cloning and analysis of the ghrelin/GHSR system in Xenopus tropicalis

General and Comparative Endocrinology, 2023
Ghrelin is a gut-derived peptide with several physiological functions, including feeding, gastrointestinal motility, and hormonal secretion. Recently, a host defense peptide, liver-expressed antimicrobial peptide-2 (LEAP2), was reported as an endogenous antagonist of growth hormone secretagogue receptor (GHS-R).
Reiko, Wada, Shota, Takemi, Mio, Matsumoto, Mio, Iijima, Takafumi, Sakai, Ichiro, Sakata   +5 more
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LEAP2 is a more conserved ligand than ghrelin for fish GHSRs

Biochimie, 2022
ABSTRACTRecently, liver-expressed antimicrobial peptide 2 (LEAP2) was identified as an endogenous competitive antagonist and an inverse agonist of the ghrelin receptor GHSR. However, its functions in lower vertebrates are not well understood. Our recent study demonstrated that both LEAP2 and ghrelin are functional towards a fish GHSR from Latimeria ...
Hao-Zheng Li, Xiao-Xia Shao, Ya-Fen Wang, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo   +5 more
openaire   +2 more sources

The new mechanism of Ghrelin/GHSR-1a on autophagy regulation

Peptides, 2020
Autophagy is associated with several diseases. In recent years, accumulating evidence has suggested that ghrelin pathway exerts a protective effect by regulating autophagy. This review aims to assess the potential role and use of ghrelin as a new treatment for obesity, cardiovascular diseases, nonalcoholic fatty liver disease (NFALD), neurodegenerative
Ming-Jie Yuan, Tao Wang
openaire   +3 more sources

Adenosine is not a direct GHSR agonist – artificial cross‐talk between GHSR and adenosine receptor pathways

Acta Physiologica, 2007
AbstractAim: To assess if adenosine is a direct growth hormone secretagogue receptor (GHSR) agonist by investigating the mechanism behind adenosine induced calcium release in human embryonic kidney 293s (HEK) cells expressing GHSR.Methods: Calcium mobilization, cyclic adenosine monophosphate (cAMP) and IP3experiments were performed using HEK cells ...
Nils-Olov Hermansson, Niklas Larsson, Tomas Drmota, David G.A. Morgan   +3 more
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Investigation of GHSR and GHRL Methylation in Colorectal Cancer

Epigenomics, 2018
To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC) tissues and healthy adjacent mucosa.Methylation was assessed with methylation-sensitive high-resolution melting.GHSR was significantly hypermethylated in CRC tissues than in healthy mucosa (p 
Coppedè, Fabio, Stoccoro, Andrea, Lazzarotti, Alessandro, Spisni, Roberto, Migliore, Lucia   +4 more
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Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis

Gene, 2020
Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia ...
Coppede F., Stoccoro A., Nicoli V., Gallo R., De Rosa A., Guida M., Maestri M., Lucchi M., Ricciardi R., Migliore L.   +9 more
openaire   +3 more sources

Associations of GHSR gene polymorphisms with chicken growth and carcass traits [PDF]

Molecular Biology Reports, 2009
Ghrelin receptor (GHSR), or growth hormone secretagogue receptor, modulates many physiological effects by binding to its ligand and therefore is a candidate gene for chicken production performance. In this study, five polymorphisms (four SNP and a 'GGTACA' indel) of GHSR gene were genotyped in a F(2) full sib chicken population to investigate their ...
Dexiang Zhang, Chenlong Luo, Qinghua Nie, Xiquan Zhang, Meixia Fang   +4 more
openaire   +2 more sources

The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice

Neuropharmacology, 2019
Ghrelin is an orexigenic hormone that also plays an important role in mood disorders. Our previous studies demonstrated that ghrelin administration could protect against depression-like behaviors of chronic unpredictable mild stress (CUMS) in rodents. However, the mechanism related to the effect of ghrelin on CUMS mice has yet to be revealed.
Bing Li, Qiuqin Han, Rui Yu, Gen-Cheng Wu, Yan-Qing Wang, Qiong Liu, Jin Yu, Jing Wang, Hui-Jie Huang, Adam Pilot, Xiao-Rong Chen   +10 more
openaire   +3 more sources

Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity

Bioorganic & Medicinal Chemistry Letters, 2010
Piperazine-bisamide analogs were discovered as partial agonists of human growth hormone secretagogue receptor (GHSR) in a high throughput screen. The partial agonists were optimized for potency and converted into antagonists through structure-activity relationship (SAR) studies.
Malgorzata Wanska, Lingming Liang, Alykhan Motani, Ji Ma, Alex Zhang, Michelle Lindstrom, Holger Beckmann, Cong Li, Leping Li, Richard V. Connors, Julio C. Medina, Ming Yu, Kang Dai, Katrin Haller, Mike Lizarzaburu   +14 more
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