Results 71 to 80 of about 8,260 (216)

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension [PDF]

, 2004
We investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH).
Baptista, MJ, Brandão-Nogueira, A, Correia-Pinto, J, Fortunato, JM, Henriques-Coelho, T, Leite-Moreira, AF, Lourenço, AP, Oliveira, SM, Roncon-Albuquerque R, Jr., Teles, A   +9 more
core   +1 more source

Expression of Ghrelin and GHSR-1a in Long Term Diabetic Rat's Kidney [PDF]

Brazilian Archives of Biology and Technology, 2016
The aim of this work was to study the relative ghrelin and growth hormone secretagogue receptor (GHS-R)1a gene expression in the kidney of long-term diabetic rats. Forty male Wistar albino rats were divided into four groups: C- control group, DI- one month diabetic rats group, DII- two months diabetic rats group, and DIII- three months diabetic rats ...
Yildirim, Aysegul Burcin, Karabulut, Derya, Dundar, Munis, Ulusoy, Hasan Basri, Sonmez, Mehmet Fatih   +4 more
openaire   +4 more sources

Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom [PDF]

, 2015
The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain–blood barrier (BBB) imposes, the interplay between these two ...
Cabral, Agustina, De Francesco, Pablo, Perelló, Mario   +2 more
core   +6 more sources

Neuroprotective actions of ghrelin and growth hormone secretagogues [PDF]

, 2011
The brain incorporates and coordinates information based on the hormonal environment, receiving information from peripheral tissues through the circulation.
Laura M. Frago, Laura M. Frago, Laura M. Frago, Laura M. Frago, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Jesús eArgente, Jesús eArgente, Jesús eArgente, Jesús eArgente, Julie A Chowen, Julie A Chowen, Julie A Chowen   +14 more
core   +1 more source

Bladder Cancer detection by urinary methylation markers GHSR/MAL: a validation study

World Journal of Urology
Abstract Purpose Although cystoscopy is a reliable tool for detecting bladder cancer, it poses a high burden on patients and entails high costs. This highlights the need for non-invasive and cost-effective alternatives. This study aimed to validate a previously developed urinary methylation marker panel containing GHSR ...
Beijert, I. J., van den Burgt, Y., Hentschel, A. E., Bosschieter, J., Kauer, P. C., Lissenberg-Witte, B. I., van Moorselaar, R. J. A., Nieuwenhuijzen, J. A., Steenbergen, R. D. M.   +8 more
openaire   +3 more sources

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

Communications Biology
The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding ...
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio   +22 more
doaj   +1 more source

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation

Frontiers in Immunology
Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition.
Hongying Wang, Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G. Geoffroy, Sunja Kim, David Threadgill, David Threadgill, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun   +15 more
doaj   +1 more source

Ghrelin mediates exercise endurance and the feeding response post-exercise

Molecular Metabolism, 2018
Objective: Exercise training has several well-established health benefits, including many related to body weight, appetite control, and blood glucose homeostasis. However, the molecular mechanisms and, in particular, the hormonal systems that mediate and
Bharath K. Mani, Carlos M. Castorena, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Nathan P. Metzger, Joel K. Elmquist, Jeffrey M. Zigman   +6 more
doaj   +1 more source

Allosteric modulation of ghrelin receptor signaling by lipids

Nature Communications, 2021
The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects ...
Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M’Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M. Bisch, Jean-Alain Fehrentz, Laurent J. Catoire, Nicolas Floquet, Jean-Louis Banères   +11 more
doaj   +1 more source

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
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