Results 71 to 80 of about 3,121 (172)

Mutations in the ghrelin receptor gene GHSR in congenital hypopituitarism [PDF]

Problems of Endocrinology, 2017
The results of molecular genetic studies indicate the potential involvement of ghrelin in the pathogenesis of some dwarfism forms. However, in the case of isolated somatotropin insufficiency, mutations in the ghrelin receptor gene are a rare cause of the disease.
Elena A. Serebryakova, Andrey S. Glotov, Elena B. Bashnina, Mariia E. Turkunova, Vladislav S Baranov, Oleg S. Glotov, Olga Berseneva   +6 more
openaire   +2 more sources

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension [PDF]

, 2004
We investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH).
Baptista, MJ, Brandão-Nogueira, A, Correia-Pinto, J, Fortunato, JM, Henriques-Coelho, T, Leite-Moreira, AF, Lourenço, AP, Oliveira, SM, Roncon-Albuquerque R, Jr., Teles, A   +9 more
core   +1 more source

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits [PDF]

, 2016
The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including ...
Aschard, H. (Hugues), Bandinelli, S. (Stefania), Beekman, M. (Marian), Berndt, S.I. (Sonja), Bidlingmaier, M. (Martin), Broer, L. (Linda), Cappola, A.R. (Anne), Ceda, G.P. (Gian Paolo), Chanock, S.J. (Stephen), Chen, M.-H. (Ming-Huei), Chen, T.C. (Tai C.), Chen, Y.D. (Y.), Chung, J. (Jonathan), Del Greco Miglianico, F. (Fabiola), Duijn, C.M. (Cornelia) van, Eriksson, J. (Joel), Ferrucci, L. (Luigi), Friedrich, N. (Nele), Gnewuch, C. (Carsten), Goodarzi, M. (Mark), Grarup, N. (Niels), Guo, T. (Tingwei), Hammer, E. (Elke), Hayes, R.B. (Richard), Heemst, D. (Diana) van, Hicks, A.A. (Andrew), Hofman, A. (Albert), Houwing-Duistermaat, J.J. (Jeanine), Hu, F. (Frank), Hunter, D. (David), Husemoen, L.L.N. (Lise Lotte), Isaacs, A.J. (Aaron), Jacobs, K.B. (Kevin), Janssen, J.A.M.J.L. (Joop), Jansson, J.-O. (John-Olov), Jehmlich, N. (Nico), Johnson, S. (Simon), Juul, A. (Anders), Kaplan, R.C. (Robert), Karlsson, M. (Magnus), Kilpeläinen, T.O. (Tuomas), Kovacs, P. (Peter), Kraft, P. (Peter), Li, C. (Chao), Linneberg, A. (Allan), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lorentzon, M. (Mattias), Lu, Y. (Yingchang), Maggio, M. (Marcello), Meigs, J.B. (James), Mellström, D. (Dan), Mägi, R. (Reedik), Nauck, M. (Matthias), Nethander, M. (Maria), Newman, A.B. (Anne B.), Ohlsson, C. (Claes), Pollak, M.N. (Michael), Pramstaller, P.P. (Peter Paul), Prokopenko, I. (Inga), Psaty, B.M. (Bruce), Qi, Q., Reincke, M. (Martin), Rimm, E.B. (Eric B.), Rotter, J.I. (Jerome I.), Saint Pierre, A. (Aude), Schurmann, C. (Claudia), Seshadri, S. (Sudha), Sjögren, K. (Klara), Slagboom, P.E. (Eline), Strickler, H.D. (Howard D.), Stumvoll, M. (Michael), Suh, Y. (Yousin), Sun, Q. (Qi), Svensson, J. (Johan), Tanaka, T. (Toshiko), Tare, A. (Archana), Teumer, A. (Alexander), Tönjes, A. (Anke), Uh, H.-W. (Hae-Won), Vandenput, L. (Liesbeth), Vasan, R.S. (Ramachandran Srini), Völker, U. (Uwe), Wallaschofski, H. (Henri), Willems, S.M. (Sara), Zhang, C. (Cuilin)   +85 more
core   +1 more source

Nucleotide polymorphisms of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene and their association with growth and carcass traits in Japanese Black cattle [PDF]

, 2010
Ghrelin growth hormone secretagogue receptor 1a (GHSR1a) is involved in many important functions, including growth hormone secretion and food intake (Howard et al. 1996).
Fujimori, Y, Itoh, T, Komatsu, M, Malau-Aduli, AEO, Sato, Y, Satoh, M, Takahashi, H   +6 more
core   +3 more sources

Allosteric modulation of ghrelin receptor signaling by lipids

Nature Communications, 2021
The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects ...
Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M’Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M. Bisch, Jean-Alain Fehrentz, Laurent J. Catoire, Nicolas Floquet, Jean-Louis Banères   +11 more
doaj   +1 more source

Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts. [PDF]

, 2015
Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis,
Casati, L, Mrak, E, Pagani, F, Rubinacci, A, Sibilia, V, Zarattini, G   +5 more
core   +4 more sources

A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia

Advanced Science, 2023
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood.
Tingting Yi, Na Wang, Jing Huang, Yaling Wang, Shuancheng Ren, Yiwen Hu, Jianxia Xia, Yixiang Liao, Xin Li, Fenlan Luo, Qin Ouyang, Yu Li, Ziyi Zheng, Qin Xiao, Rong Ren, Zhongxiang Yao, Xiangdong Tang, Yanjiang Wang, Xiaowei Chen, Chao He, Hong Li, Zhian Hu   +21 more
doaj   +1 more source

Catestatin and GABAAR related feeding habits rely on dopamine, ghrelin plus leptin neuroreceptor expression variations [PDF]

, 2016
Catestatin (CST), an endogenously small sympathoinhibitory peptide is capable of interfering with the major cerebral neuroreceptor-blocking site, i.e. γ-aminobutyric acidA receptor (GABAAR) system especially in limbic brain areas that are involved with ...
Alò, Raffaella, Avolio, Ennio, Canonaco, Marcello, Carelli, Antonio, Fazzari, Gilda, IACHETTA, GIUSEPPINA, LAFORGIA, VINCENZA, Mele, Maria   +7 more
core   +1 more source

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation

Frontiers in Immunology
Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition.
Hongying Wang, Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G. Geoffroy, Sunja Kim, David Threadgill, David Threadgill, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun   +15 more
doaj   +1 more source

Immunohistochemical and hybridocytochemical study on ghrelin signalling in the rat seminiferous epithelium.

Folia Histochemica et Cytobiologica, 2010
The results of presented study demonstrate expression of ghrelin, its functional receptor GHSR-1a and their genes in spermatogenic cells of rat testis suggesting their functioning within seminiferous epithelium.
Marcin Ruciński, Karolina Olejniczak, Aldona Kasprzak, Piotr Sawiński, Ludmiła Rafińska, Andrzej Łukaszyk, Marek Ruchała, Jerzy Sowiński   +7 more
doaj   +1 more source