Integrating the inputs that shape pancreatic islet hormone release. [PDF]
, 2019 The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
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Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders
Frontiers in NutritionGhrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning.
Yunxiao Ma +4 more
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Molecular and Neuroendocrine Determinants of Seasonal Body Weight Regulation [PDF]
, 2005 This thesis deals with the characterisation of neuroendocrine pathways involved in seasonal body regulation revealed by the Siberian hamster (Phodopus sungorus).
Klingenspor, Martin (Dr.) +1 more
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Molecular MetabolismObjective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim +13 more
doaj +1 more source
Screening of GHSR, GHRHR, GH1 genes in isolated growth hormone deficiency disease in Egyptian patients [PDF]
Egyptian Journal of Medical Human GeneticsBackground Isolated growth hormone deficiency (IGHD) is a hereditary disorder that causes significant short stature. GHD has a reported incidence of 1/4000–1/10,000 births.
Tamer H. A. Ammar +5 more
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Chloride Balance in Preterm Infants during the First Week of Life
International Journal of Pediatrics, 2012 Objective. To describe the chloride balance in infants born 25–32-week gestation, analyze the association of chloride changes with hydroelectrolytic status and their relationship with perinatal conditions, morbidities, and neurological outcome.
Silvia Iacobelli +4 more
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Ghrelin mediates exercise endurance and the feeding response post-exercise
Molecular Metabolism, 2018 Objective: Exercise training has several well-established health benefits, including many related to body weight, appetite control, and blood glucose homeostasis. However, the molecular mechanisms and, in particular, the hormonal systems that mediate and
Bharath K. Mani +6 more
doaj +1 more source
Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Nature Communications, 2021 Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as ‘hunger hormone’ and signals through its GPCR, GHSR.
Heng Liu +6 more
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Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom [PDF]
, 2015 The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain–blood barrier (BBB) imposes, the interplay between these two ...
Cabral, Agustina +2 more
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Relationship between abnormal symptoms of Prader-Willi syndrome model --Snord116 deletion mice and Ghrelin signaling pathway [PDF]
, 2016 Prader–Willi综合症是以进食异常和血液Ghrelin异常升高为特征的遗传肥胖症。其病因是Snord116SnoRNA群的表达缺失。我们构建的Snord116del小鼠模型表现出贪食和血液Ghrelin升高等PWS症状。此次研究中，我们繁育野生型（WT）、Snord116del（SW）、Ghrl-/-（WG）、Ghsr-/-（WR）小鼠，并制备[Snord116del，Ghrl-/-]（SG）和[Snord116del，Ghsr-/-]（SR）双敲除小鼠，对其生长发育 ...
甘利芬
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