Results 51 to 60 of about 541,742 (239)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

open access: yesAdvanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin   +7 more
wiley   +1 more source

Enhancing Creative Reading through Self-Questioning and Enrichment Activities

open access: yesMarifetname
Enrichment programs aim to develop thinking and creativity skills among gifted individuals across various fields, including the linguistic domain.
Zelal Aboud
doaj   +1 more source

An enrichment philosophy and strategy for empowering young gifted children to become autonomous learners [PDF]

open access: yes, 2000
A goal of gifted education is to enable gifted children to become autonomous learners and, as adults, creative participants in society. In this study, we have implemented a program in which young children are provided with opportunities to become ...
Diezmann, Carmel M., Watters, James J.
core  

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

open access: yesAdvanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami   +7 more
wiley   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee   +3 more
wiley   +1 more source

Reconceptualizing teacher preparation for gifted learners in inclusive education: differentiation as a structuring principle of professional readiness

open access: yesFrontiers in Education
The article examines teacher preparation for working with gifted learners in inclusive education by positioning differentiated instruction as a structuring principle of professional readiness. The study aimed to develop and pilot a theoretically grounded
Daniyar Utegulov   +4 more
doaj   +1 more source

Proceedings of the Gifted and Talented Education Symposium 2022: Diversity and Gifted Education [PDF]

open access: yes, 2022
Gifted and Talented Symposium Diversity and Gifted Education (Virtual Event) Held on Friday 27 May 2022 Dr Michelle Ronksley-Pavia from Griffith University led this year’s virtual Gifted and Talented Education Symposium with a focus on the theme of ...
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core  

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

open access: yesAdvanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan   +5 more
wiley   +1 more source

Which career cycle might facilitate students’ development following teachers’ gifted education training?

open access: yesFrontiers in Psychology
IntroductionThe educational philosophy advocating that “students from all economic and cultural backgrounds should reach their full potential” has not extended to the most capable student cohort, leaving gifted students underserved. Over the past decade,
Xiling Qin   +4 more
doaj   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

open access: yesAdvanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola   +10 more
wiley   +1 more source

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