Results 61 to 70 of about 2,402 (156)

Heme Competition Triggers an Increase in the Pathogenic Potential of Porphyromonas gingivalis in Porphyromonas gingivalis-Candida albicans Mixed Biofilm

Frontiers in Microbiology, 2020
As one of the main pathogens of periodontitis, Porphyromonas gingivalis often forms mixed biofilms with other bacteria or fungi under the gingiva, such as Candida albicans. Heme is an important iron source for P. gingivalis and C.
Yanyang Guo, Yu Wang, Yijin Wang, Yabing Jin, Chen Wang   +4 more
doaj   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains

MicrobiologyOpen, 2023
Periodontitis is an inflammatory condition caused by bacteria and represents a serious health problem worldwide as the inflammation damages the supporting tissues of the teeth and may predispose to systemic diseases.
Helene R. Haugsten, Anne K. Kristoffersen, Trude M. Haug, Tine M. Søland, Reidun Øvstebø, Hans C. D. Aass, Morten Enersen, Hilde K. Galtung   +7 more
doaj   +1 more source

Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease

Frontiers in Neuroscience, 2021
“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles consisting of ...
Ingar Olsen
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Proteolytic effects of gingipains on trefoil factor family peptides

Clinical Oral Investigations, 2017
The present study was aimed to determine whether trefoil factor family (TFF) peptides which were generally considered to be resistant to proteolysis could be digested by gingipains, a major proteinases produced by Porphyromonas gingivalis.Recombinant human TFF1, TFF2, and TFF3 peptides were used as substrates.
Chaiyarit, Ponlatham, Jaresitthikunchai, Janthima, Phaonakrop, Narumon, Roytrakul, Sittiruk, Potempa, Barbara, Potempa, Jan   +5 more
openaire   +3 more sources

Binding Specificity of the Porphyromonas gingivalis Heme and Hemoglobin Receptor HmuR, Gingipain K, and Gingipain R1 for Heme, Porphyrins, and Metalloporphyrins [PDF]

Journal of Bacteriology, 2001
ABSTRACT Previous genetic and biochemical studies have confirmed that hemoglobin and hemin utilization in Porphyromonas gingivalis is mediated by the outer membrane hemoglobin and heme receptor HmuR, as well as gingipain K (Kgp), a lysine-specific cysteine protease, and gingipain R1 (HRgpA), one of two ...
T, Olczak, D W, Dixon, C A, Genco
openaire   +2 more sources

Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal diseases

Japanese Dental Science Review, 2017
Porphyromonas gingivalis (P. gingivalis) is a major oral pathogen and associated with periodontal diseases including periodontitis and alveolar bone loss. In this review, we indicate that two virulence factors, which are hemoglobin receptor protein (HbR)
Masaaki Nakayama, Naoya Ohara
doaj   +1 more source

Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains. [PDF]

PLoS ONE, 2013
The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell surface receptor of the immunoglobulin superfamily, with the capacity to amplify pro-inflammatory cytokine production and regulate apoptosis. Polymorphonuclear neutrophils (PMNs) are
Nagihan Bostanci, Thomas Thurnheer, Joseph Aduse-Opoku, Michael A Curtis, Annelies S Zinkernagel, Georgios N Belibasakis   +5 more
doaj   +1 more source