Results 101 to 110 of about 41,073 (260)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Improved Extraction Method and Chromatographic Separation of Ginsenosides from Ginseng Roots, Leaves and Ginseng Drug Preparations

, 2013
A new extraction method for ginsenosides from ginseng roots,ginseng leaves and ginseng drug preparations by Sep-Pak C/sub 18/ cartridges has been studied. Ginsenoside extraction by Sep-Pak cartridges is a rapid, efficient, reproducible method.
薛文發; Sye, Wen-fa; 蔡百豐; Tsai, Pai-feng
core   +1 more source

In-Depth Investigation on Potential Mechanism of Forest-Grown Ginseng Alleviating Alzheimer’s Disease via UHPLC-MS-Based Metabolomics

Metabolites
Background: Alzheimer’s disease is a central nervous system degenerative disease closely related to age with a complex pathogenesis. As a natural medicinal plant, forest-grown ginseng (GSF) contains abundant ginsenosides and offers significant ...
Huazhou Niu, Meng Zhang, Kaiyue Zhang, Saibire Aishan, Hui Li, Wei Wu   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture

, 2007
A standardized aqueous extract of Panax ginseng radix was tested for its antioxidant effect on primary astrocytes culture on an oxidant stress model generated by H2O2.
Naval López, María Victoria, Gómez-Serranillos Cuadrado, María Pilar, Villar Del Fresno, Ángel, Carretero Accame, María Emilia   +3 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Ginsenoside Re Inhibits ROS/ASK-1 Dependent Mitochondrial Apoptosis Pathway and Activation of Nrf2-Antioxidant Response in Beta-Amyloid-Challenged SH-SY5Y Cells

Molecules, 2019
Accumulation of amyloid-β (Aβ), which results in the formation of senile plaques that cause oxidative damage and neuronal cell death, has been accepted as the major pathological mechanism of Alzheimer’s disease (AD).
Meichen Liu, Xueyuan Bai, Shiting Yu, Wenxue Zhao, Juhui Qiao, Ying Liu, Daqing Zhao, Jiawen Wang, Siming Wang   +8 more
doaj   +1 more source

The flavor impact of G-Rg1 and G-Rb1 on the taste perception of ginseng

, 2011
Ginseng has become a common ingredient used by makers of energy drinks who wish to infer that their product contains memory enhancing capabilities. As studies conducted on its main bioactive compounds (ginsenosides), have shown promise in producing not ...
Steadman, Rachel F.
core  

Harnessing Gut Microbiota to Enhance Immunotherapy in NSCLC: From Mechanisms to Translational Applications

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT The gut microbiome has emerged as a pivotal regulator of immunotherapy efficacy in non‐small cell lung cancer (NSCLC), with mounting evidence demonstrating that microbial‐immune crosstalk significantly influences therapeutic responses. Current research reveals that commensal bacteria modulate host immunity through complex metabolic and ...
Liming Zhu, Jiayao Xu, Dong Niu, Xiangyu Zhang, Chunhui Jin   +4 more
wiley   +1 more source