Results 151 to 160 of about 51,810 (321)

Induction of apoptosis in Lewis lung carcinoma cells by an intestinal bacterial metabolite produced from orally administered ginseng protopanaxadiol saponins [PDF]

, 2000
The present study demonstrated that oral administration of an intestinal bacterial metabolite (M1) of protopanaxadiol-type saponin significantly inhibited the tumor growth at the implantation site after intrapulmonary implantation of Lewis lung carcinoma
Hasegawa Hideo, Murakami Koji, Saiki Ikuo, Suda Kazuhito   +3 more
core   +1 more source

Glucose‐Lowering Properties of a Tea Formulation Containing Citrullus lanatus Peel, Ananas comosus Peel, and Mentha spicata L. Leaf Extracts in Dexamethasone‐Induced Insulin‐Resistant Wistar Rats

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The optimized tea blend exhibited high antioxidant activity and contained significant amounts of flavonoids, tannins, polyphenols, and vitamin C. In diabetic rats, the tea formulation significantly improved glycemic control, reduced lipid profiles, and enhanced liver and kidney function.
Irwin Leoda Begnone, Laurette Blandine Mezajoug Kenfack, Rosane Matsinkou Soh   +2 more
wiley   +1 more source

Macaranga peltata Alleviates Neuropsychiatric Disorders in Mouse Model and Computational Study

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The methanol extract of Macaranga peltata leaves (MEMPL) exhibited notable neuropharmacological and analgesic properties in rodents. Phytochemical and GC–MS analyses confirmed diverse bioactive compounds. MEMPL (200–400 mg/kg) showed anxiolytic, antidepressant, CNS depressant, and antinociceptive effects, comparable to standard drugs.
Shaifullah Mansur Tanzil, Ahmed Azizul Hakim, Md Tasaffiul Islam, Farhan Tanvir, Israt Jahan, Arafat Faraque, Syed Mohammed Tareq, Md Areeful Haque, Md Amjad Hossen, Md. Shohel Al Faruk, Kazi Ashfak Ahmed Chowdhury, Mohammad Nazmul Islam   +11 more
wiley   +1 more source

A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke [PDF]

, 2015
Chenglong Xie, Wenwen Wang, Xiaodong Xue, Sufang Zhang, Jing Gan, Zhenguo Liu   +5 more
openalex   +1 more source

Role of Macrophages in Cardiac Remodeling: Cues From Zebrafish Heart

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
The figure illustrates the role of macrophage polarization in cardiac damage and repair, highlighting monocyte to M0, M1, and M2 macrophage differentiation. M1 macrophages, in response to pro‐inflammatory cytokines (e.g., IFNγ, TNF‐α, IL‐6), are involved in fibrosis and scarring in the heart.
Himanshu Gaur, Maram Hasan, Huseyin C. Yalcin   +2 more
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Biotransformation of Ginsenoside Rb1 to Ginsenoside Rd and 7 Rare Ginsenosides Using Irpex lacteus with HPLC-HRMS/MS Identification

ACS Omega
The biotransformation of ginsenosides using microorganisms represents a promising and ecofriendly approach for the production of rare ginsenosides. The present study reports on the biotransformation of ginsenoside Rb1 using the fungus Irpex lacteus, resulting in the production of ginsenoside Rd and seven rare ginsenosides with novel structures ...
Yue Gao, Yadong Feng, Yanyan Chang, Zhu Zhu, Huanxi Zhao, Wei Xu, Mengya Zhao, Yusheng Xiao, Lu Tian, Yang Xiu   +9 more
openaire   +3 more sources

The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia–Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome‐Lysosome Fusion

Cell Proliferation, Volume 59, Issue 1, January 2026.
The present study revealed the neuroprotective effect of ginsenoside Rg1 against cerebral ischemia–reperfusion injury through inhibition of mitophagy via blocking mitophagosome‐lysosome fusion both in vivo and in vitro models. ABSTRACT Ginsenoside Rg1 has shown promise in ameliorating cerebral ischemia–reperfusion injury (CIRI).
Lin Ai, Hangui Ren, Yuan Wang, Mengfan Liu, Yufei Qiu, Jiling Feng, Rongchen Dai, Wang Fu, Yongpeng Wang, Zhichao Xi, Hongxi Xu, Feng Wang   +11 more
wiley   +1 more source

Ginsenoside Rb1 ameliorates neutrophil extracellular traps-induced vascular endothelial damage by suppressing apoptosis

Bangladesh Journal of Pharmacology
The study aims to investigate the effect of ginsenoside Rb1 on improving neutrophil extracellular traps-induced vascular endothelial damage. The CCK8 assay was used to evaluate the impact of ginsenoside Rb1 on cell activity.
Biao Zhang, Junkai Zhao, Jiamin Yin, Jiaping Chen, Lingqi Xu   +4 more
doaj   +1 more source