Results 81 to 90 of about 17,049 (209)

Korean Red Ginseng Attenuates Dysfunctions and Modulates Inflammatory and Neuroplasticity Markers in the Harmaline‐Induced Model of Essential Tremor

Brain and Behavior, Volume 16, Issue 6, June 2026.
Korean red Ginseng significantly reduces tremor severity, improves motor coordination, and ameliorates anxiety and cognitive deficits in a mouse model of essential tremor through suppression of neuroinflammatory markers and normalization of neuroplasticity genes in the cerebellum.
Monavareh Soti, Mehran Ilaghi, Leila Bagherzadeh, Fatemeh Shahsavari, Kristi A. Kohlmeier, Zeynab Pirmoradi, Mohammad Shabani   +6 more
wiley   +1 more source

Antiallergic Activity of Ginsenoside Rh2

Biological & Pharmaceutical Bulletin, 2003
The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a main metabolite, had the most potent inhibitory activity on beta-hexosaminidase release from RBL-2H3 cells and in the passive cutaneous ...
Park, Eun-Kyung, Choo, Min-Kyung, Kim, Eun-Jin, Han, Myung Joo, Kim, Dong-Hyun   +4 more
openaire   +3 more sources

Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro

Drug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT Santamarine (SAMA), a Michelia compressa‐derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated SAMA and cisplatin's combined effects and underlying ROS/MAPK mechanisms of action on oral cancer cells ...
Hsin‐I. Lu, Kuan‐Liang Chen, Chung‐Yi Chen, Ching‐Yu Yen, Ammad Ahmad Farooqi, Tsu‐Ming Chien, Jiiang‐Huei Jeng, Bing‐Hung Chen, Hsueh‐Wei Chang   +8 more
wiley   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway

Frontiers in Pharmacology
IntroductionTriple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and underlying ...
Rumeng Ding, Quancheng Kan, Ting Wang, Ran Xiao, Yanan Song, Duolu Li   +5 more
doaj   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Analysis of Saponins in Two Processed American Ginseng Products Based on UHPLC-Q-Orbitrap-MS/MS

Zhipu Xuebao
Ultra-high performance liquid chromatography-quadrupole-electrostatic field orbital trap high-resolution mass spectrometry (UHPLC-Q-Orbitrap-MS/MS) was used to analyze the saponin components in sun-dried American ginseng and red American ginseng.
Ye JING, Li-wen LIANG, Yu-lin DAI, Fei ZHENG, Yang WANG, Xin HUANG, Yun-long GUO, Hao YUE   +7 more
doaj   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Hepatoprotective Potential of Walnut Oil Unsaponifiable Matter on Aging‐Induced Liver Injury via Gut Microbiota–Liver Axis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
USM protects against aging‐induced liver injury by modulating the gut‐liver axis. It enriches beneficial microbiota (e.g., Akkermansia and Lactobacillus) and upregulates tight junction proteins (ZO‐1, Occludin, Claudin) to restore the intestinal barrier.
Junjun Zhou, Dan Hong, Rujin Bai, Xinhui Wang, Shijie Zhu, Qiming Tian, Junxia Xia, Zhou Chen, Siting Li, Yingmin Jia, Aijin Ma   +10 more
wiley   +1 more source

Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway

Journal of Inflammation Research, 2022
Chenyang Zhang,1 Meixin Han,2 Xuelian Zhang,1 Hongna Tong,1 Xiaobo Sun,1 Guibo Sun1 1Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2College of Pharmacy,
Zhang C, Han M, Zhang X, Tong H, Sun X, Sun G   +5 more
doaj