Results 91 to 100 of about 8,127 (213)

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Ginsenoside Rb1 and mitochondria: A short review of the literature

Molecular and Cellular Probes, 2019
Mitochondria play a central role in various critical cellular processes, including energy synthesis, energy supply and apoptosis. Panax notoginseng, a commonly used traditional Chinese medicine, has various pharmacological effects on the human body. Ginsenosides are representative bioactive components of P. notoginseng.
Ping Zhou, Weijie Xie, Yifan Sun, Ziru Dai, Guang Li, Guibo Sun, Xiaobo Sun   +6 more
openaire   +2 more sources

A review study on medicinal plants affecting amnesia through cholinergic system [PDF]

, 2012
Neurotransmitter modification is an important method for the treatment of memory loss or amnesia. Cholinomimetic drugs, particularly, acetylcholine esterase inhibitors are the mainstream in pharmacotherapy of amnesia. Donepezil, tacrine, galantamine, and
Baradaran, Azar., Rabiei, Zahra., Rafieian, Morteza., shirzad, Hedayatollah.   +3 more
core  

Magnesium Structure‐Function Integration Platform for Spatiotemporal Multi‐Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer

Advanced Science, Volume 13, Issue 12, 27 February 2026.
The schematic illustration of the MHSCG platform for spatiotemporal responsive GRb1 release to induce androgen deprivation therapy (ADT) and immunogenic cell death (ICD) multimodal therapy in prostate cancer. Abstract Metal‐based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited
Rui Zan, Qianping Mao, Keyi Wang, Guodong Zou, Shi Yang, Hua Qiu, Xiang Fang, Guiqing Wang, Xinyi Zhou, Jiexia Wen, Shuai Jiang, Ran Huang, Qiuming Peng, Tao Suo   +13 more
wiley   +1 more source

Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis

Journal of Orthopaedic Translation, 2016
Osteoarthritis (OA) is the most common degenerative joint disorder. Inflammatory cytokine plays an important role in OA progression. Previous studies have demonstrated that ginsenoside Rb1 would prevent inflammation and apoptosis in chondrocytes. However, we have not found any animal study reporting that Rb1 attenuates the severity of OA.In this study,
Chen Yuanfeng, LinSien, Sun Yuxin, Pan Xiaohua, Xiao Liubin, Zou Liyi, Ho Ki Wai, Li Gang   +7 more
openaire   +4 more sources

Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis

Molecules, 2017
In traditional Chinese medicine practice, drying method is an essential factor to influence the components of Chinese medicinal herbs. In this study, an ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-
Xin-fang Xu, Shu-ya Xu, Ying Zhang, Hui Zhang, Meng-nan Liu, Huan Liu, Yan Gao, Xue Xue, Hui Xiong, Rui-chao Lin, Xiang-ri Li   +10 more
doaj   +1 more source

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice [PDF]

, 2009
Background Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than conventional therapy or anti ...
Tai-Guo Liu, Ying Huang, Dan-Dan Cui, Xiao-Bing Huang, Shu-Hua Mao, Ling-Ling Ji, Hai-Bo Song, Cheng Yi, R Abe, PY Yue, SS Lakka, M Nagpal, J Chen, TM Xu, Y Wu, H Morioka, D Hanahan, JM Hou, M Colleoni, G Klement, L Bello, RP Dings, CL Reimer, B Liu, W Lu, DD Adler, N Weidner, J Folkman, LW Hertel, CJ van Moorsel, VO Lewis, C Magnon, MS Kim, J Folkman, H Bando, DF Hayes, RR Maria, G Gasparini, Q Zhang, KS Park, CJ Sweeney, CP Jung, P Huang, K Keyes, R Munoz, Y Cui, CX Liu, K Fujita, CI Coleman, AS Attele, DO Kennedy, WK Khalil   +51 more
core   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells

Artificial Cells, Nanomedicine, and Biotechnology, 2019
To study the effects of ginsenoside Rb1 and the molecular mechanisms on proliferation and apoptosis of uterine fibroid cells, Rb1 + pc DNA3.1, Rb1 + pc DNA3.1-HMGB1, si-NC or si-HMGB1 was transfected into uterine fibroid cells by liposome method; the ...
Jianqiang Zhang, Jing Wang, Xinan Wu, Yuhui Wei   +3 more
doaj   +1 more source

Ginsenoside Rg3 Ameliorates Psoriasis‐Like Dermatitis through Inhibition of NF‐κB/NLRP3 Inflammasome Signaling and Regulating Th17/Treg Balance

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Psoriasis, characterized as a persistent cutaneous inflammatory condition driven by aberrant immunity, exhibits pathogenesis and disease course heavily influenced by sustained inflammatory activity. Ginsenoside Rg3 (Grg3), a traditional Chinese medicinal compound, has shown notable therapeutic effects on various inflammatory ...
Liyun Gao, Qingge Xie, Zhaoli Zhou, Wanlu Zhang, Huiya Sun, Zhen Yue, Congjun Jiang   +6 more
wiley   +1 more source