Results 181 to 190 of about 8,127 (213)

Isolation of ginsenoside Rb1 fromKalopanax pictus by eastern blotting using anti-ginsenoside Rb1 monoclonal antibody

Phytotherapy Research, 2005
Araliaceous species containing ginsenosides, the major active component in Panax species, were surveyed using ELISA and eastern blotting with anti-ginsenoside Rb1 monoclonal antibody. Immunoassay-guided fractionation of the methanol-soluble extracts of Araliaceous species led to the isolation of a known compound in the bark of Kalopanax pictus Nakai ...
Hiroyuki, Tanaka, Noriko, Fukuda, Shoji, Yahara, Susumu, Isoda, Chun-Su, Yuan, Yukihiro, Shoyama   +5 more
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Ginsenoside Rb1 and Rg3 Attenuate Glucocorticoid-Induced Neurotoxicity

Cellular and Molecular Neurobiology, 2010
Glucocorticoid (GC) hormones, increased in response to stress, can cause neuronal loss. We tested the effect of GC hormone on cell viability of neural SHSY-5Y cells and protective effects of ginsenoside Rb1 and Rg3 on the action of GC. We treated SHSY-5Y cells with increasing concentrations of synthetic GC dexamethasone (DEX; 10, 25, 50, and 100 nM ...
Sung-Ok, Kim, Jung-Man, You, Su-Jin, Yun, Min-Sook, Son, Kyong Nyon, Nam, Joung-Woo, Hong, Sun Yeou, Kim, Sang Yoon, Choi, Eunjoo H, Lee   +8 more
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Biotransformation of Ginsenoside Rb1 to Ginsenoside CK by Strain XD101: a Safe Bioconversion Strategy

Applied Biochemistry and Biotechnology, 2021
Ginsenoside Rb1 is the main predominant component in Panax species. In this study, an eco-friendly and convenient preparation method for ginsenoside CK has been established, and five strains of β-glucosidase-producing microorganisms were screened out from the soil of a Panax notoginseng planting field using Esculin-R2A agar.
Yunyun Jiang, Weina Li, Daidi Fan
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Pharmacokinetic Study of Ginsenosides Rb1 and Rg1 in Rat by ELISA Using Anti-ginsenosides Rb1 and Rg1 Monoclonal Antibodies

The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao, Yukihiro, Shoyama, Hiroyuki, Tanaka   +2 more
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Ginsenoside Rb1 blocks Homocysteine-induced endothelial dysfunction

Journal of Surgical Research, 2004
Abstract Background. Homocysteine (HCY) is an independent risk factor for atherosclerosis. This study is to investigate the effect of ginsenoside Rb1, a major constituent of ginseng, on HCY-induced endothelial dysfunction and molecular changes in porcine coronary arteries. Methods.
W. Zhou, H. Chai, P. Lin, A.B. Lumsden, C. Chen, C. Chen   +5 more
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Ginsenoside Rb1 Directly Scavenges Hydroxyl Radical and Hypochlorous Acid

Current Pharmaceutical Design, 2012
Reactive oxygen species (ROS) have been implicated in a variety of inflammatory diseases including cardiovascular disease (CVD), cancer, diabetes, Alzheimer's disease, autism, cataracts and aging. When endogenous mechanisms for the maintenance of redox homeostasis are overwhelmed, dietary intake of antioxidants contributes substantially to balancing ...
Jian-Ming, Lü, Sarah M, Weakley, Zhen, Yang, Ming, Hu, Qizhi, Yao, Changyi, Chen   +5 more
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Ginsenoside Rb1: The new treatment measure of myasthenia gravis

International Immunopharmacology, 2016
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fatigue and muscle weakness. Ginseng is used in the treatment of MG. Ginsenoside Rb1 (G-Rb1), the most abundant ginsenoside in ginseng root, has been proved to be immune regulatory in various diseases.
Wei, Chen, Qing-Fang, Meng, Jun-Kang, Sui, Yan-Jun, Wang, Xiao-Li, Li, Shen, Liu, Heng, Li, Cong-Cong, Wang, Chun-Hong, Li, Yan-Bin, Li   +9 more
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Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis

Oral Diseases
AbstractObjectivesThe objectives of current study were to investigate the role and related mechanism of Ginsenoside Rb1 (GRb1) on regulating apical periodontitis (AP) prognosis.Materials and MethodsClinical specimens were used to determine the involvement of calcium overload‐induced macrophage pyroptosis in periapical tissues.
Xiaoyue Guan, Rui Zhao, Yuting Wang, Wenlan Li, Lifei Pan, Yao Yang, Wenli Mu, Tie Zhou Hou   +7 more
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[Advance of pharmacological study on ginsenoside Rb1].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system ...
Ji-ming, Jia, Zong-quan, Wang, Li-jun, Wu, Yi-ling, Wu   +3 more
openaire   +1 more source

Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals

Chemico-Biological Interactions, 2020
Ginsenoside Rb1 (GsRb1) is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic, antioxidative and antirheumatic agent, its oral bioavailability is poor due to its limited solubility. In this study, the solubility of GsRb1 was improved by encapsulating it in polymeric nanocapsules (encapsulation efficiency: 99.79%
Yuan, Liu, Haiyang, Zhu, Wei, Zhou, Qing, Ye   +3 more
openaire   +2 more sources