Results 1 to 10 of about 7,976 (200)

Pharmacokinetics study of ginsenoside Rg1 liposome by pulmonary administration [PDF]

Heliyon
Ginsenoside Rg1 (Rg1), a monomer saponin component, is one of the components with the highest content in total saponins of Panaxnotoginseng. It had various pharmacological effects.
Ping Liang, Jie Zhang, Juan Hou, Rui Feng, Jintuo Yin   +4 more
doaj   +4 more sources

Does ginsenoside Rg1 promote intervertebral disc repair? An experimental study insights into ferroptosis mechanism [PDF]

Journal of Translational Medicine
Background Intervertebral disc degeneration (IVDD) is a complex and multifactorial condition characterized by the progressive deterioration of the intervertebral discs.
Dongliang Gong, Feiyun Xia, Fuyong Wang, Xiaoxia Tong, Qing Yang, Kelv Shen, Baihan Sun, Nong Chen, Zhengfeng Lu   +8 more
doaj   +2 more sources

A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway [PDF]

Pharmaceutical Biology
Context The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction.
Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun   +9 more
doaj   +2 more sources

Ginsenoside Rg1 Ameliorates Pulmonary Hypertension by Inhibiting cGAS/STING Mediated Cell Senescence [PDF]

Drug Design, Development and Therapy
Rongzhen Ding,1– 3 Haiping Xie,4 Yu Zhang,2,3 Li Qin,3,5 Guoran Peng,2,3 Jian Yi,2,3 Junlan Tan,6 Xianya Cao,2,3 Runxiu Zheng,2,3 Aiguo Dai2 1Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan ...
Ding R, Xie H, Zhang Y, Qin L, Peng G, Yi J, Tan J, Cao X, Zheng R, Dai A   +9 more
doaj   +2 more sources

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation [PDF]

Renal Failure
Background The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of
Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang   +9 more
doaj   +2 more sources

Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis [PDF]

Frontiers in Pharmacology
BackgroundThe pathological progression from liver injury to fibrosis is a hallmark of liver disease, with no effective strategies to halt this transition.
Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng   +10 more
doaj   +2 more sources

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism

Frontiers in Pharmacology, 2023
Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies.
Chaofang Lei, Jiaxu Chen, Jiaxu Chen, Zhen Huang, Yinian Men, Yue Qian, Mingzhi Yu, Xinyi Xu, Lin Li, Xin Zhao, Youming Jiang, Yueyun Liu   +11 more
doaj   +1 more source

Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2022
Purpose Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which not only affects patients’ life quality, but also places a great burden on the public health system.
Yong-hua Yang, Xiao-peng Gu, Hong Hu, Bin Hu, Xiang-lian Wan, Zhi-ping Gu, Shao-jin Zhong   +6 more
doaj   +1 more source

Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]

, 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Bonati, Laura, Denison, Michael S, Fraccalvieri, Domenico, He, Guochun, Hu, Qin, Soshilov, Anatoly, Xie, Qunhui, Yin, Huijun, Zhang, Aiqian, Zhao, Bin, Zhao, Jing   +10 more
core   +6 more sources

Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline

Frontiers in Immunology, 2023
IntroductionIn recent years, numerous studies have confirmed that chronic stress is closely related to the development of cancer. Our previous research showed that high levels of stress hormones secreted in the body during chronic stress could inhibit ...
Yuqian Zhu, Jingyao Chen, Jun Li, Chenqi Zhou, Xin Huang, Bingdi Chen   +5 more
doaj   +1 more source