Results 11 to 20 of about 7,976 (200)

Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression

Journal of Ginseng Research, 2022
Background: Although the tumor-suppressive effects of ginsenosides in cell cycle have been well established, their pharmacological properties in mitosis have not been clarified yet.
Jihee Hong, Dasom Gwon, Chang-Young Jang
doaj   +3 more sources

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine. [PDF]

Food Sci Nutr
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Cortés H, Lima E, Duarte-Peña L, Peña-Corona SI, Almarhoon ZM, Kaverikana R, Mangalpady SS, Shet VB, Manjeshwar N, Sharifi-Rad J, Chen JT, Leyva-Gómez G, Setzer WN, Calina D.   +13 more
europepmc   +2 more sources

The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion. [PDF]

Cell Prolif
The present study revealed the neuroprotective effect of ginsenoside Rg1 against cerebral ischemia–reperfusion injury through inhibition of mitophagy via blocking mitophagosome‐lysosome fusion both in vivo and in vitro models. ABSTRACT Ginsenoside Rg1 has shown promise in ameliorating cerebral ischemia–reperfusion injury (CIRI).
Ai L, Ren H, Wang Y, Liu M, Qiu Y, Feng J, Dai R, Fu W, Wang Y, Xi Z, Xu H, Wang F.   +11 more
europepmc   +2 more sources

Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy

Journal of Ginseng Research, 2023
Alzheimer's disease (AD) is a common form of dementia, and impaired mitophagy is a hallmark of AD. Mitophagy is mitochondrial-specific autophagy. Ginsenosides from Ginseng involve in autophagy in cancer. Ginsenoside Rg1 (Rg1 hereafter), a single compound of Ginseng, has neuroprotective effects on AD.
Ni Wang, Junyan Yang, Ruijun Chen, Yunyun Liu, Shunjie Liu, Yining Pan, Qingfeng Lei, Yuzhou Wang, Lu He, Youqiang Song, Zhong Li   +10 more
openaire   +3 more sources

Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus

Gut Microbes, 2023
Morphine addiction is closely associated with dysbiosis of the gut microbiota. miRNAs play a crucial role in regulating intestinal bacterial growth and are involved in the development of disease.
Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo   +6 more
doaj   +1 more source

Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation [PDF]

Acta Pharmacologica Sinica, 2009
To investigate the effect of ginsenoside Rg1 on the migration, adhesion, proliferation, and VEGF expression of endothelial progenitor cells (EPCs).EPCs were isolated from human peripheral blood and incubated with different concentrations of ginsenoside Rg1 (0.1, 0.5, 1.0, and 5.0 micromol/L) and vehicle controls.
Ai-wu, Shi, Xiao-bin, Wang, Feng-xiang, Lu, Min-min, Zhu, Xiang-qing, Kong, Ke-jiang, Cao   +5 more
openaire   +2 more sources

Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3

Animals, 2023
Abnormal function and the fibrosis of endometrium caused by endometritis in cows may lead to difficult embryo implantation and uterine cavity adhesions. Emerging evidence indicates that ginsenoside Rg1 can effectively resist inflammation and pathological
Liangli Song, Linnan Wang, Xiangchen Li, Longfei Xiao   +3 more
doaj   +1 more source

Activities of β-Glucosidase and α-L-Arabinofuranosidase from Cordyceps militaris and Their Applications in the Transformation of Ginsenoside Rg1 and Rc [PDF]

Shipin Kexue, 2023
In this study, a strain of Cordyceps militaris with high productivity of β-glucosidase was identified and selected. The effects of carbon source, nitrogen source and pH value on the production of β-glucosidase, α-L-arabinofuranosidase, cordyceps acid and
LI Fei, HUANG Qiuting, SUI Xin, XIE Ying
doaj   +1 more source

Antioxidant and anti-inflammatory properties of ginsenoside Rg1 for hyperglycemia in type 2 diabetes mellitus: systematic reviews and meta-analyses of animal studies

Frontiers in Pharmacology, 2023
Background: According to existing laboratory data, ginsenoside Rg1 may help cure diabetes and its complications by reducing oxidative stress (OS) and managing inflammation. However, this conclusion lacks reliability and is unclear.
Qian Xie, Xiaoran Zhang, Qian Zhou, Yumei Xu, Lisha Sun, Qing Wen, Wei Wang, Qiu Chen   +7 more
doaj   +1 more source

Protective effect of ginsenoside Rg1 on attenuating anti-GBM glomerular nephritis by activating NRF2 signalling

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background/Aim Ginsenoside Rg1 exerts a beneficial effect in many kidney diseases. But little work has been done to confirm whether ginsenoside Rg1 could also exert a protective effect on anti-glomerular basement membrane (anti-GBM) glomerular nephritis (
Xiaojuan Guo, Jingyuan Zhang, Min Liu, Guo Chen Zhao   +3 more
doaj   +1 more source