Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression
Journal of Ginseng Research, 2022 Background: Although the tumor-suppressive effects of ginsenosides in cell cycle have been well established, their pharmacological properties in mitosis have not been clarified yet.
Jihee Hong, Dasom Gwon, Chang-Young Jang
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A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke [PDF]
Scientific Reports, 2015 The neuroprotective actions of Ginsenoside-Rg1 (G-Rg1) have been documented for experimental stroke therapy. We used a systematic review and meta-analysis to assess the efficacy of G-Rg1 in experimental ischemic stroke. We identified studies describing the efficacy of G-Rg1 in animal models of focal cerebral ischemia.
Chenglong Xie +5 more
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Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of ginsenoside Rg1 on lipid deposition in a cell model of non-alcoholic fatty liver disease (NAFLD) and explore the molecular mechanism.
XIAO Qing +4 more
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Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 pathway in mice. [PDF]
Psychopharmacology (Berl)Li J +8 more
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Ginsenoside Rg1 attenuates asthma features in mice co-exposed to house dust mite allergen and diesel exhaust particle by modulating epithelial ILC2 interactions. [PDF]
J Ginseng ResLee HS, Park HW.
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Protective effect of ginsenoside Rg1 on lidocaine-induced apoptosis
Molecular Medicine Reports, 2013 Lidocaine, as an anesthetic substance, is often used for surface and spinal anesthesia. However, studies have shown that lidocaine may induce transient neurological symptoms and cauda equina syndrome. In the present study the effects of the ginsenoside Rg1 (Rg1) on lidocaine‑induced apoptosis were assessed in Jurkat cells using flow cytometry and ...
Hui Li, Junmei Xu, Xin Wang, Guixiu Yuan
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Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway [PDF]
Journal of Ginseng ResearchBackground: Hypoxic pulmonary hypertension (HPH) is the main pathological change in vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some research results have shown that ginsenoside Rg1 (Rg1) can improve vascular remodeling, but
Chenyang Ran +7 more
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Enzymatic transglycosylation of ginsenoside Rg1 by rice seed α-glucosidase [PDF]
Bioscience, Biotechnology, and Biochemistry, 2015 Abstract Six α-monoglucosyl derivatives of ginsenoside Rg1 (G-Rg1) were synthesized by transglycosylation reaction of rice seed α-glucosidase in the reaction mixture containing maltose as a glucosyl donor and G-Rg1 as an acceptor. Their chemical structures were identified by spectroscopic analysis, and the effects of reaction time, pH ...
Min‐Ji Kim +4 more
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The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion. [PDF]
Cell ProlifThe present study revealed the neuroprotective effect of ginsenoside Rg1 against cerebral ischemia–reperfusion injury through inhibition of mitophagy via blocking mitophagosome‐lysosome fusion both in vivo and in vitro models. ABSTRACT Ginsenoside Rg1 has shown promise in ameliorating cerebral ischemia–reperfusion injury (CIRI).
Ai L +11 more
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Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism-Like Behaviors in a Valproic Acid Induced Male Mouse Model. [PDF]
Kaohsiung J Med SciABSTRACT This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism‐like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (600 mg/kg) on embryonic Day 12.5 to establish an autism model.
Song FX +8 more
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