Results 1 to 10 of about 20,751 (192)

Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway [PDF]

BMC Complementary Medicine and Therapies
Background Ginsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of cell death characterized by oxidative damage to phospholipids. The purpose of this study was to examine
GuoFu Zhong, Junteng Chen, Yangtao Li, Yue Han, Maosheng Wang, Qinqi Nie, Mujuan Xu, Qinghua Zhu, Xiao Chang, Ling Wang   +9 more
doaj   +3 more sources

Ginsenoside Rg3 inhibits the malignant progression of cervical cancer cell by regulating AKT2 expression [PDF]

Heliyon, 2023
Although ginsenoside Rg3 has been shown to exert anticancer effects in various malignancies, the effects and molecular mechanisms of ginsenoside Rg3 in cervical cancer (CC) remain unclear.
Hui Liu, Tingting Xie, Yuan Liu
doaj   +2 more sources

Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent

Frontiers in Pharmacology, 2022
Inflammation and oxidative stress lead to various acute or chronic diseases, including pneumonia, liver and kidney injury, cardiovascular and cerebrovascular diseases, metabolic diseases, and cancer.
Jing Wang, Jing Wang, Li Zeng, Ying Zhang, Wenxiu Qi, Ziyuan Wang, Lin Tian, Daqing Zhao, Qibiao Wu, Qibiao Wu, Xiangyan Li, Tan Wang   +11 more
doaj   +2 more sources

Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis. [PDF]

ISME J, 2023
The microbiota-associated factors that influence host susceptibility and immunity to enteric viral infections remain poorly defined. We identified that the herbal monomer ginsenoside Rg3 (Rg3) can shape the gut microbiota composition, enriching robust ...
Wang G, Liu J, Zhang Y, Xie J, Chen S, Shi Y, Shi F, Zhu SJ.   +7 more
europepmc   +2 more sources

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Frontiers in Genetics, 2022
Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with the mechanisms being not well clarified, which results in the cancer recurrence and poor ...
Xiaofeng Wang, Rui He, Li Geng, Jing Yuan, Huijie Fan   +4 more
doaj   +2 more sources

Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR-γ. [PDF]

Int J Mol Sci, 2023
Ginsenoside Rg3 extracted from Panax notoginseng has therapeutic effects on diabetes and heart diseases. However, the underlying mechanism of ginsenoside Rg3 on diabetic cardiomyopathy (DCM) remains unclear.
Zhang C, Yu H, Ye J, Tong H, Wang M, Sun G.   +5 more
europepmc   +2 more sources

Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice

Journal of Ginseng Research, 2021
Background: Ginsenoside Rg3, isolated from Panax ginseng, has anti-inflammatory and anti-tumor activities. It is known to reduce inflammation in acute lung injury in mice, and to reduce the expression of inflammatory cytokines and COX-2 in human ...
Wen-Chung Huang, Tse-Hung Huang, Kuo-Wei Yeh, Ya-Ling Chen, Szu-Chuan Shen, Chian-Jiun Liou   +5 more
doaj   +2 more sources

Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's Disease. [PDF]

Adv Sci (Weinh)
Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through a comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as a compound capable ...
Qi LF, Liu S, Fang Q, Qian C, Peng C, Liu Y, Yang P, Wu P, Shan L, Cui Q, Hua Q, Yang S, Ye C, Yang W, Li P, Xu X.   +15 more
europepmc   +2 more sources

Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment. [PDF]

Regen Biomater
The skin stratum corneum (SC) barrier function will interfere with the absorption of topical treatment and reduce the drug's therapeutic effect on alopecia. Microneedles (MNs) can penetrate the skin barrier and deliver drugs to the dermis.
Yang Q, Guo P, Lei P, Yang Q, Liu Y, Tian Y, Shi W, Zhu C, Lei M, Zeng R, Zhang C, Qu Y.   +11 more
europepmc   +2 more sources

Ginsenoside Rg3 targets glycosylation of PD-L1 to enhance anti-tumor immunity in non-small cell lung cancer. [PDF]

Front Immunol
Background Reactivate the T cell immunity by PD-1/PD-L1 checkpoint blockade is widely used in non-small cell lung cancer (NSCLC) patients, while the post-translational modification of Programmed death ligand-1 (PD-L1) is commonly existed in various ...
Wang W, Kong M, Shen F, Li P, Chen C, Li Y, Li C, Qian Z, Zhong A, Wang Y, Yang L, He F, Li W.   +12 more
europepmc   +2 more sources