Ginsenoside Rg3 induces mesangial cells proliferation and attenuates apoptosis by miR-216a-5p/MAPK pathway in diabetic kidney disease. [PDF]
Aging (Albany NY)Background: Ginsenoside Rg3 is an active saponin isolated from ginseng, which can reduce renal inflammation. However, the role and mechanism of Rg3 in diabetic kidney disease (DKD) are far from being studied.
Chen Y, Peng Y, Li P, Jiang Y, Song D.
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Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. [PDF]
Cell CycleThis investigation examined the potential of ginsenoside Rg3 in addressing traumatic brain injury (TBI). A TBI mouse model underwent treatment with ginsenoside Rg3 and nicotinamide (NAM).
Liu X +7 more
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Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation [PDF]
BMC Pulmonary Medicine, 2021 Background Excessive fibroblast proliferation during pulmonary fibrosis leads to structural abnormalities in lung tissue and causes hypoxia and cell injury. However, the mechanisms and effective treatment are still limited.
Zhuo Fu, Yong-sheng Xu, Chun-quan Cai
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Ginsenoside Rg3 Ameliorates Psoriasis-Like Dermatitis through Inhibition of NF-κB/NLRP3 Inflammasome Signaling and Regulating Th17/Treg Balance. [PDF]
Immun Inflamm DisABSTRACT Background Psoriasis, characterized as a persistent cutaneous inflammatory condition driven by aberrant immunity, exhibits pathogenesis and disease course heavily influenced by sustained inflammatory activity. Ginsenoside Rg3 (Grg3), a traditional Chinese medicinal compound, has shown notable therapeutic effects on various inflammatory ...
Gao L +6 more
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Network Analysis of 20S-Ginsenoside Rg3 Effect on Human Colorectal Adenocarcinoma Cell Line HT-29 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: 20S-Ginsenoside Rg3 is a pharmacological active compound of ginseng. Evidences indicate that S20-Rg3 as an anti-cancer factor plays role in prevention and treatment of cancer.
Mona Zamanian Azodi +5 more
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Journal of Advanced Research, 2022 Graphical abstract A schematic illustration of Rg3-PTX-LPs to reverse cancer drug resistance. (A) Ginsenoside Rg3 substitutes cholesterol as the membrane material in preparing Rg3-PTX-LPs.
Ying Zhu +8 more
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Relationship Between Ginsenoside Rg3 and Metabolic Syndrome [PDF]
Frontiers in Pharmacology, 2020 Metabolic syndrome is an important public health issue and is associated with a more affluent lifestyle. Many studies of metabolic syndrome have been reported, but its pathogenesis remains unclear and there is no effective treatment. The ability of natural compounds to ameliorate metabolic syndrome is currently under investigation.
Hyunji Lee +12 more
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Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1 [PDF]
Frontiers in Cell and Developmental Biology, 2021 Graphical AbstractGinsenoside Rg3 promotes cell growth through activation of mTORC1 and increasing mitochondrial biogenesis.
Wei Liu +13 more
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Journal of Ginseng Research, 2022 Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular ...
Jingyu Ni +11 more
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Ginsenoside Rg3 attenuates fat accumulation in zebrafish with high-fat-diet-induced obesity
Pharmacological Research - Modern Chinese Medicine, 2022 Ginsenoside Rg3 is one of major steroidal saponins in Panax ginseng that has demonstrated several therapeutic effects. In this study, we investigated the effects of ginsenoside Rg3 on lipid accumulation in a high-fat diet (HFD) larval zebrafish model by ...
Fei Li +4 more
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